International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2009.236.239Drupa margariticola]]>ChellaramC. EdwardJ.K. Patterson 3200953The extract of gastropod, Drupa margariticola tested for their analgesic assets using chemical (acetic acid) induced and hot plate method on Swiss mice model showed promising results. One hundred percent column purified extracts of the D. margariticola (25 and 100 mg kg -1 p.o.) exhibited significant (p<0.001) writhing inhibition of 65 and 78.57%, respectively against acetic acid induced abdominal constrictions. The result of hot plate study, in the difference between the mean reaction time and increased percentage of jump response of test animals in the treated groups, control and standard groups were statistically significant (p<0.001). At 30 min, the mean reaction time for extracts (50 mg kg -1 p.o.) group was 6.67 ±1 sec, when compared to control group (2.67 ±0.52 sec) and pentazocine treated groups (11.5 ±1.22 sec) for 100 mg kg -1 p.o. These facts suggest that the 100% acetone fraction of the D. margariticola was shown the strongest analgesic action. The important results obtained in present study were central and peripheral analgesic activities demonstrated by the inhibitory action on the acetic acid induced writhings and hot plate models. The hot plate method was found to be suitable in the evaluation of centrally acting analgesic action but not for peripherally acting analgesic action.]]>Chellaram, C., K.M.E. Gnanambal and J.K.P. Edward,2004Pteria chinensis (Pterioida: Pteridae).]]>33369372Faulkner, D.J.,200077135145Fenical, W.,199715339341Gavagnin, M., M. Carbone, E. Mollo and G. Cimino,20035955795583Karuso, P. and P.J. Scheuer,2002Nembrotha kubaryana, Hypselodoris infucata and Chromodoris petechialis.]]>716Kokke, W.C.M.C., S. Epstein, S.A. Look, G.H. Rau, W. Fenical and C. Djerassi,198425981688173Koster, R., M. Anderson and E.J. de Beer,195918412412Look, S.A., W. Fenical, R.S. Jacobs and J. Clardy,1986Pseudopterogorgia elisabethae.]]>8362386240Mandal, S.K., R. Boominathan, B. Parimaladevi, S. Dewanjee and C. Mandal,2005Eupatorium adenophorum Sreng. Leaves.]]>43662663Mayer, A.M.S. and V.K.B. Lehmann,20012124892500nks, N.R., C. Lerner, A.T. Henriques, F.M. Farias and E.S.E. Schapoval,et al., 2002281112Ray, S.B. and L.T. Yaksh,2008448260262Avila, C., K. Iken, A. Fontana and G. Cimino,2000Bathydoris hodgsoni Eliot, 1907: Defensive role and origin of its natural products.]]>33135Sung, P.J., H.H. Gwo, T.Y. Fan, J.J. Li, J. Dong, C.C. Han, S.L. Wu and L.S. Fang,2004Junceella.]]>32185196Tsukamoto, S., S. Matsunaga, N. Fusetani and R.W. van Soest,1998Acanthodendrilla sp.]]>6113741378Turner, M.A.,19651st Edn.,pp: 106pp: 106