International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2009.222.227Coccinia grandis Leaves Against Carbon Tetrachloride Induced Hepatic Injury in Rats]]>SunilsonJ. Anbu Jeba MuthappanM. DasAmitava SurajR. VaratharajanR. PromwichitP. 3200953Coccinia grandis Linn. (Cucurbitaceae) is a perennial branched handsome tendril climber, distributed through out India. It has been used in folk medicine for the treatment of jaundice. The aim of this work was to study the hepatoprotective effect of crude ethanolic and aqueous extracts from the leaves of C. grandis against liver damage induced by CCl4 in rats. The ethanolic extract at an oral dose of 200 mg kg -1 exhibited a significant (p<0.05) protective effect as shown by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase, total bilirubin and total cholesterol and increasing levels of total protein and albumin levels as compared to silymarin, the positive control. These biochemical observations were supported by histopathological examination of liver sections. The activity may be due to the presence of flavonoid compounds. The extracts showed no signs of acute toxicity up to a dose level of 2000 mg kg -1. Thus it could be concluded that ethanolic extract of C. grandis leaves possesses significant hepatoprotective activity.]]>Ashok, S.K., S.N. Somayaji and K.L. Bairy,2001Gingko biloba against carbon tetrachloride induced hepatic injury in rats.]]>33260266Bose, A., S. Mondal, J.K. Gupta, T. Ghosh, G.K. Dash and S. Si,2007Cleome rutidosperma.]]>78515520Bugno, A., M.A. Nicoletti, A.A.B. Almodovar, T.C. Pereira and M.T. Auricchio,2007Curcuma zedoaria extract as assessed by linear regression compared with commercial mouthrinses.]]>38440445Celik, I., T. Atilla and I. Ismail,2009Punica granatum) flowers infusion against trichloroacetic acid-exposed in rats.]]>47145149Galigher, A.E. and E.N. Kozloff,19712nd Edn.,Handa, S.S. and A. Sharma,1990Andrographis paniculata against carbon tetrachloride.]]>92276283Kumar, S.V.S. and S.H. Mishra,2005Cyperus rotundus Linn. against carbon tetrachloride induced hepatotoxicity.]]>678488Makni, M., H. Fetoui, N.K. Gargouri, E.M. Garoui and H. Jaber et al.,20084637143720McComb, R.B. and G.N. Bowers, Jr.,19721897104OECD.,1998Peters, T.,19681411471159Rajkapoor, B., B. Jayakar, N. Murugesh and D. Sakthisekaran,2006Bauhinia variegata against N-nitrosodiethylamine induced liver tumors and human cancer cell lines.]]>104407409Rana, M.G., R.V. Katbamna, A.V. Dudhrejiya and N.R. Sheth,2008Tecomella undulata against experimentally induced liver injury in rats.]]>3674682Reddy, B.P., C.K. Kokate, D. Rambhau, V. Venkateshwarlu and V.N. Murthy,199255137140Richmond, W.,1973Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum.]]>1913501356Sabir, S.M. and J.B.T. Rocha,2008Solanum fastigiatum (false Jurubeba) against paracetamol-induced liver damage in mice.]]>120226232Kumara, S.S., B.R. Kumara and G.K. Mohan,2009Trichosanthes cucumerina Var cucumerina L. on carbon tetrachloride induced liver damage in rats.]]>2009Savita, S., K. Arvind, S. Srivastava, G.K. Patnaik and S.B.N. Dhawan,1994261922Sreelatha, S., P.R. Padma and M. Umadevi,2009Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity in rats.]]>47702708Sumathi, T. and A. Nongbri,2008Bacopa monniera Linn.]]>15901905Sunilson, J., J. Anbu, P. Jayaraj, S. Mohan, A.G. Kumari and R. Varatharajan,2008Hibiscus esculentus Linn.]]>2200203Swamy, B.M.V., G.S. Kumar, S.I. Shiva kumar, H.M. Suresh, U. Rajashekar and C. Sreedhar,2007Coccinia grandis Linn. Against Carbon Tetrachloride Induced Liver Damage in Wistar Rat.]]>1925502554Tandon, V.R., V. Khajuria, B. Kapoor, D. Kour and S. Gupta,2008Vitex negundo leaf extract against anti-tubercular drugs induced hepatotoxicity.]]>79533538Umamaheswari, M. and C.T. Kumar,2008Coccinia grandis against paracetamol-induced hepatic damage in mice.]]>2103107Vadivu, R., A. Krithika, C. Biplab, P. Dedeepya, N. Shoeb and K.S. Lakshmi,2008Coccinia grandis Linn.]]>1163168Wagner, H. and S. Bladt,19962nd Edn.,Pages: 384Pages: 384Warrier, P.K., V.P.K. Nambiar and C. Ramakutty,1995Vol. 4,Webster, D.,197453109115Zeashan, H., G. Amresh, S. Singh and C.V. Rao2008Amaranthus spinosus in experimental animals.]]>4634173421Geetu, S., G. Prasoon, R. Preeti, P. Anju, B. Gitika and M. Rakesh,2007Coccinia grandis in high-fat diet-fed hamster model.]]>14792798Tannin-Spitz, T., M. Bergman and S. Grossman, 2007364181186