International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2008.60.63Plasmodium berghei berghei Infection in Mice]]>OreagbaA.I. AinaO.O. AwodeleO. OlayemiS.O. MabadejeA.F.B. AshorobiR.B. 1200841Grapefruit juice was assessed for chemoprophylactic
activity against Chloroquine-sensitive Plasmodium berghei berghei
infection in mice. A standard inoculum of 1x106 infected erythrocytes
was used to assess the prophylactic effect of grapefruit juice (15 mL
kg-1) and this was compared with the prophylactic effect of
high dose Ascorbic acid (150 mg mL-1 or 2.25 g kg-1).
The result of the experiment showed that grapefruit juice and high dose
vitamin C significantly delayed the establishment of parasitaemia compared
with the control group. Furthermore, grapefruit juice and ascorbic acid
prolonged the mean survival time of the mice with corresponding decreases
in mean peak percentage parasitaemia, respectively. Grapefruit juice however
demonstrated a stronger chemoprophylactic activity than ascorbic acid
(p<0.05). These effects were however lower than the standard prophylactic
drug (Pyrimethamine-1.2 mg kg-1). Regular intake of grape juice
may protect against malaria infection. Further studies are necessary to
elucidate possible mechanisms involved.]]>Adelekan, D.A. and D.I. Thurnham,1998Plasmodium berghei malaria.]]>79305309Metzger, A., G. Mukasa, A.H. Shankar, G. Ndeezi, G. Melikian and R.D. Semba,200165115119Ansari, K.U., N. Kastury, S.L. Tewarson, S.P. Singh and R.C. Pandey,1998309496Awodele, O., M.O. Araoye, A.I. Oreagba and S.K. Akindele,2006Plasmodium berghei infected mice.]]>57478Ayori, M., T. Hisada, M. Suzukawa and H. Yoshida,2000108105108Gambhir, J.K., P. Lali and A.K. Jain,199730351355Golenser, J. and M. Chevion,198926313325Hassan, G.I., U. Gregory and H. Maryam,20048378381Isamah, G.K. and Asagba,2003Plasmodium falciparum infection on the levels of Malondialdehyde (MDA) and ascorbic acid on Nigerian children.]]>76571Kurl, S., T.P. Tuomainen and J.A. Laukkanen et al.,20023315681573Levander, O.A., A.L. Jr. Ager, V.C. Morris and R.G. May,1989Plasmodium yoelii.]]>50346352Levine, M.,1986314892902Mahan, L.K. and S. Stump,200010th Edn.,Marva, E.J., A. Golenser, N. Cohen, R. Kitossky-Har-El and M. Chevion,1992Plasmodium falciparum.]]>431723Mohan, K., M.L. Dubey, N.K. Ganguly and R.C. Mahajan,1994Plasmodium falciparum and blood monocytes abnormalities in human erythrocyte cation homeostasis.]]>72286291Oreagba, A.I. and R.B. Ashorobi,2006Plasmodium berghei infection in mice.]]>6838842Peters, W.,1965Plasmodium berghei Vincke and Lips, 1948. I. Chloroquine resistance.]]>178089Prasannachandra, V. D'Souza and B. D'Souza,2006Falciparum and Vivax malaria.]]>21103106Serghides, L. and K.C. Kain,2002Falciparum malaria.]]>35914041406Stocker, R., M. Weidermann and N. Hunt,1986P. vinckei-infected mouse erythrocytes.]]>881391397Turner, T.V., T. Leonardi, B. Patil, M. Murphy, N. Wang and L. Pike,20042004Udenfriend, S., C.T. Clark, J. Axelrod and B.B. Brodie,1954208731739Winter, R.W., M. Ignatushchenko, O.A. Ogundahunsi, K.A. Cornell and A.M.J. Oduola et al.,19974114491454