International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2008.452.459TayebiPouya KheirkhahFarzan TayebiGouya MoghadamniaAli Akbar 6200846This study was performed to investigate the effect of
tramadol on morphine dependency and analgesia. Mice were divided into
5 groups, (1) Morphine-dependent, (2) Tramadol-dependent, (3) Morphine-dependent
accompanied by saline, (4) Morphine-dependent accompanied by tramadol
(50 mg kg-1) and (5) Tramadol 30 min pretreatment of naloxone
in the last day in morphine-dependent mice. Hot-plate, formalin and writhing
tests were applied to investigate antinociceptive effect of tramadol in
different doses (12.5, 25, 50 and 100 mg kg-1). Latency time
for jumping in group 4 (11.64 ±1.44 min) was less than group 1
(19.62 ±2.28 min) (p<0.05). The dose of 50 and 100 mg kg-1
of tramadol induced more tolerance in mice in hot-plate test. The most
of this effect is for tramadol 100 mg kg-1 30 min after beginning
the test to be controlled (p<0.05). In formalin test tramadol 50 mg
kg-1 in both acute (7.17 ±2.66 min) and chronic (19.5
±9.22 min) phases showed the most effectiveness. In writhing test
the most effective dose was 50 mg kg-1 of tramadol as well.
It seems tramadol can increase the depth of morphine dependence in mice.
Also, tramadol antinociceptive effect in high doses can appear the comparative
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