International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2008.388.392JoshuaA.J. GoudarK.S. DamodaranA. SameeraN. AmitA. 5200845The present study was conducted to evaluate the acute
oral toxicity potentials of certain herbal veterinary preparations in
albino Wistar rats. In the sighting study, the test substances were administered
in sequential manner to one animal each at 2000 and 5000 mg kg-1
body weight followed by four animals at 5000 mg kg-1 body weight
in the main study; whereas the test materials with well documented traditional
use were evaluated at 5000 mg kg-1 body weight. The treated
animals were observed for mortality, untoward clinical/toxic signs, alterations
in body weight gain and necropsy findings during the study. The treated
animals survived throughout the study period and did not reveal any treatment
related major abnormal clinical signs at the tested dose levels for all
the products. The overall percent body weight gain in rats treated with
the herbal products was found to be normal during the 14 day observation
period. On necropsy, no abnormalities were observed. In conclusion, acute
oral toxicity testing of screened herbal veterinary products did not produce
any treatment-related adverse effects upto the dose level of 5000 mg kg-1
body weight.]]>Agaie, B.M., P.A. Onyeyili, B.Y. Muhammad and M.J. Ladan, 2007Anogeissus leiocarpus in rats. ]]>6886889Aniagu, S.O., F.C. Nwinyi, D.D. Akumka, G.A. Ajoku and S. Dzarma et al.,200547278Becker, R.A., L.M. Plunkett, J.F. Borzelleca and A.M. Kaplan, 20074524542469Bhattacharjee, S.K., 19981st Edn.,pp: 384pp: 384Bulder, A. and M. Noordam, 20082008pp: 123Dadarkar, S.S., M.D. Deore and M.M. Gatne, 200747257260Department of Biotechnology (DBT), 20048716251625Francis, B.N.D., 20003rd Edn.,pp: 11pp: 11Gorniak, S.L., P.C. Maiorka, P.C. Raspantini, R. Hosomi, A.P. Moraes and M.L.Z. Dagli, 2003Solanum malacoxylon in rats. ]]>176772Hoareau, L. and E.J. DaSilva,199925670ICS-UNIDO, 20072007Jegede, O.C., J.O. Ajanusi, A.O. Adaudi and R.I.S. Agbede, 2006Spigelia anthelmia Linn on experimental Nippostrongylus braziliensis in rats. ]]>7229232Joshi, C.S., E.S. Priya and S. Venkataraman, 200753245249Lee, K.H., 20053151155Mabeku, L.B.K., V.P. Beng, J. Kouam, O. Essame and F.X. Etoa,2007Cylicodiscus gabunensis stem bark (Mimosaceae).]]>111598606Michael, H., 2007240129129Natesh, S., 20072007pp: 126Rispin, A., D. Farrar, E. Margosches, K. Gupta and K. Stitzel et al.,200250) test: The up-and-down procedure for acute oral toxicity.]]>43233243Schilter, B., C. Andersson, R. Anton, A. Constable and J. Kleiner et al.,20034116251649Sharma, P.K. and V. Singh, 1989276370Sikarwar, R.L.S., 19971997