International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2008.264.269Randia nilotica stapf. in Mice]]>M. NuhuDanjuma Abdu-AguyeIbrahim A. AnukaJoseph M. HussainiIsa U. ZeziAbdulkadir B. MaihaBilkisu SaniMalami 4200844The behavioural effects of hydroalcoholic stem bark extract of Randia nilotica on the central nervous system were investigated. The tests employed were pentobarbitone sleeping time, amphetamine stereotyped behaviour, exploratory activity, performance on treadmills (rota-rod) and mouse beam walk assay. The results revealed that the hydroalcoholic stem bark extract of Randia nilotica has significantly (p<0.001) reduced the onset of pentobarbitone sleeping time in mice and significantly prolonged (p<0.001) the duration. The results were comparable to diazepam that was used as positive control. The extract has a biphasic effect on amphetamine stereotyped behaviour in mice. There was a significant (p<0.001) reduction in jumping/climbing, but reduction in sniffing was observed only at 5 mg kg-1. Mean count in limb licking was attenuated only at 20 mg kg-1 body weight. A paradoxical increase in sniffing was observed with the extract at 20 mg kg-1 and in licking at 5 and 10 mg kg-1. No observable effect on motor coordination (rota rod, beam walk assay) was observed with the extract at the doses tested. The extract also decreased exploratory activity in mice. The results have suggested that the crude hydroalcholic extract of Randia nilotica possesses some biologically active constituents with sedative activities.]]>Amos, S., E. Kolawole, P. Akah, C. Wambebe and K. Gamaniel,2001Guiera senegalensis in mice and rats.]]>8356361Anca, J.M., M. Lamela and J.M. Calleja,1993Himanthalia elongata.]]>59218220Baldessarini, R.J.,19961996pp: 399-459. ISBN: 0-07-026266-7pp: 399-459. ISBN: 0-07-026266-7Buffett-Jerrott, S.E. and S.N. Stewart,2002845584558Chhabra, S.C., R.L.A. Mahunnah and E.N. Mshiu,199133143157Cragg, G.M., D.J. Newman and K.M. Snader,1997605260Crawley, J.N.,198593744Dalziel, J.M.,19371937Ellinwood, E.H., B. Sudilosky and L.M. Nelson,197313010881093Etkin N.L.,1988172342Farnsworth, N.R.,19941994pp: 42-59pp: 42-59Feilding, S.W. and H. Lal,19781978pp: 91-128.pp: 91-128.File, S.E. and A.G. Wardill,1975445359File, S. and S. Pellow,198586729735Fujimori, H., 19657374378Hedberg, I., O. Hedberg, P.J. Madati, K.E. Mshigeni, E.N. Mshiu and G. Samuelsson,1983Papilionaceae vitaceae.]]>9237260Lemmich, E., C. Cornett, P. Furu, C.L. Jorstian and A.D. Knudsen et al.,1995Catunaregam nilotica.]]>396368Marin-Bettulo, G.B.,1980257Miya, T.S., H.G.O. Holck, G.K.W. Yui and G.R. Spratto,1973pp: 44-46pp: 44-46Ozturk, Y., S. Aydine, R. Ben and K.H.C. Baser,1996Hypericum perforatum L. and Hypericum calycinum L. extracts on the central nervous system in mice.]]>3139146Randrup, A. and I. Munkvad,196711300310Stables, J.P. and H.J. Kupferberg,19971997pp: 191-198pp: 191-198Stanley, J.L., R.J. Lincoln, T.A. Brown, L.M. McDonald, G.R. Dawson and D.S. Reynolds,200519221227Soulimani, R., C. Younos, S. Jarmouni-Idrissi, D. Bousta, F. Khalouki and A. Laila,2001Papaver rhoeas L. in mice.]]>74265274Vogel, H.G. and W.H. Vogel,19971997pp: 208pp: 208Yemitan, O.K., A.M. Ajibade and O.O. Adeyemi,2001Dalbergia saxatillis.]]>43340Perez, G.R.M., L.J.A. Perez, D.L.M. Garcia and M.H. Sossa,1998Solanum nigrum fruit.]]>624348