International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2008.130.134Raphanus sativus L.) Against Carbon Tetrachloride-Induced Hepatotoxicity]]>RafatullahSyed Al-SheikhAbdulmalik AlqsoumiSaleh Al-YahyaMohammed El-TahirKamal GalalAhmed 2200842The fresh juice obtained from the locally grown radish
root was tested for possible hepatoprotective effect against carbon tetrachloride-induced
hepatocellular damage in albino rats. The juice at two doses of 2 and
4 mL/kg/rat for five consecutive days, exhibited a significant dose-dependent
protective effect. The magnitude of protection was measured by using biochemical
parameters including determination of Serum glutamate pyruvate transaminase
(SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase
(ALP), bilirubin (Bil) and non-protein sulfhydryl content in the liver
tissues (NP-SH), in addition to histopathological assessment. The protective
effect was demonstrated in lowering the elevated serum levels of SGPT,
SGOT, Bil, ALP and increasing NP-SH level. Silymarin, a known hepatoprotective
agent was used as a positive control. Biochemical data were further supported
by the histopathological results. The phytochemical examination of the
fresh juice revealed the presence of sulfurated, phenolic and terpenoid
compounds in radish.]]>Akgul, A.,1993pp: 79-81pp: 79-81Ankri, S. and D. Mirelman,19991125129Baghalian, K., S.A. Ziaib, M.R. Naghavic, H. Naghdi-Badib and A. Khalighia,2005Allium sativum L.) ecotypes.]]>103155166Baruchin, A.M., A. Sagi, B. Yoffe and M. Ronen,200127781782Brans, T.A., R.P. Dutrieux, M.J. Hoekstra, R.W. Kreis and J.S. du Pont,199420S48S51Celiini, L., B. Di Campli, M. Masulli, S. Di Bartolomeo and N. Aliocati,1996Helicobacter pylori by Garlic extract.]]>13273277Chowdhury, A.K., M. Ahsan, S.N. Islam and Z.U. Ahed,1991933336Cooper, A.J.L. and J.T. Pinto,200569209220Dietz, D.M., J.R. Varcelotti and K.R. Stahlfeld,200430612613Ellmore, G.S. and R.S. Feldberg,1994Allium sativum).]]>818994Gonzalez-Fandos, E., M.L. Garcia-Lopez, M.L. Sierra and A. Otero,199477549552Graham, H.D. and E.J.F. Graham,1987Aspergillus parasiticus growth and toxin production by garlic.]]>8101108Haciseferogullari, H., M. Ozcan, F. Demir and S. Calisir,2005Allium sativum L.).]]>68463469Harris, L.C., S.L. Cottrel and S. Plummer, 2001Allium sativum (garlic).]]>57282286Holzgartner, H., U. Schmidt and U. Kuhn,19923A88Hosseini, A., 19881st Edn.,pp: 26-32pp: 26-32Heinach, P.K. and D.L. Larry,1996Allium sativum L. and Related Species.]]>2nd Edn.,pp: 62-64pp: 62-64Lawson, L.D.,19961996pp: 37-108pp: 37-108Naguib, Y.,2002526Reuter, H.D., H.P. Koch and L.D. Lawson,19961996pp: 135-213pp: 135-213Saifzadeh, S., A. Tehrani, F. Shokouhi Sabet Jalali and R. Oroujzadeh,2006511011104Sardari, K., A. Mirshahi, M. Maleki, M.R. Aslani and M.N. Barjasteh,2006Histological aspects).]]>1598102Sardari, K., M.M. Dehgan, M. Mohri, M.R. Emami and A. Mirshahi et al.,200615231235Shadkchan, Y., E. Shemesh, D. Mirelman, T. Miron, A. Rabinkov, M. Wilchek and N. Osherov,2004Aspergillus sp. in vitro and in a murine model of disseminated aspergillosis.]]>53832836Sharma, G.P. and S. Prasad,2001Allium sativum) cloves by microwave-hot air combination.]]>5099105Shukla, Y. and P. Taneja,2002313136Sivam, G.P., 2001Helicobacter pylori and other bacterial infections by garlic.]]>1311106S1108SZaika, L.L.,1988997118