International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2007.385.392Bacopa monneira Against Isoproterenol-Induced Myocardial Necrosis in Rats]]>NandaveMukesh OjhaShreesh K.JoshiSujata KumariSantosh AryaDharamvir S.5200735The effects of standardized hydro-alcoholic lyophilized extract of Bacopa monneira (Bm) in isoproterenol (ISP)-induced myocardial necrosis were studied. Wistar albino male rats were randomly divided to sham, ISP control and Bacopa monneira treated groups. Bacopa monneira was administered in doses of 50, 100, 150 or 200 mg kg-1 orally for 30 days to Bacopa monneira treated groups while sham and ISP control groups received saline orally for the same duration. On day 29 and 30, ISP (85 mg kg-1) was administered subcutaneously at an interval of 24 h to ISP control and Bacopa monneira treated groups. On day 31, hemodynamic parameters were recorded before all rats were sacrificed. Hearts were excised and processed for biochemical, histopathological and ultrastructural assessment. Significant cardiac dysfunction, decline in endogenous antioxidant defence [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) and reduced glutathione (GSH)], myocyte specific injury markers [myocardial lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) isoenzyme] as well as increase in lipid peroxidation marker [malonaldialdehyde (MDA)] were observed in ISP control group as compared to sham control. Of the different doses studied, Bacopa monneira (150 mg kg-1) produced maximum cardioprotection as evidenced by significant restoration of endogenous antioxidants, myocardial LDH and CK-MB isoenzyme activities and decrease in MDA. Histopathological and ultrastructural findings also reconfirmed the cardioprotective effect of the extract. The significance of these results is discussed in relation to cardioprotective effects of Bacopa monneira against ISP-induced cardiotoxicity.]]>Aebi, H.,19741974pp: 673-678pp: 673-678Bhattacharya, S.K., A. Bhattacharya, A. Kumar and S. Ghosal,2000Bacopa monniera in rat frontal cortex, striatum and hippocampus.]]>14174179Cabaud, P.G. and F. Wroblewski,195830234236Chauhan, G.M. and S.R. Naik,200555161Cuzzocrea, S., D.P. Riley, A.P. Caputi and D. Salvemini,200153135159Deodato, B., D. Altavilla, G. Squadrito, G.M. Campo and M. Arlotta et al.,199912816831690Dhalla, K.S., H. Rupp, R.E. Beamish and N.S. Dhalla,19962+ transport due to excess catecholamines.]]>10231238Dhalla, N.S., A.B. Elmoselhi, T. Hata and N. Makino,200047446456Diaz-Munoz, M., M.A. Alvarez-Perez, L. Yanez, S. Vidrio and L. Martinez et al.,2006289125136Hanna, J., R. Chahine, G. Aftimos, M. Nader, A. Mounayar, F. Esseily and S. Chamat,200456189194Kalyanaraman, B., C.C. Felix and R.C. Sealy,1984259354358Kamboj, V.P.,2000783539Khalid, M.A. and M. Ashraf,199372725736Lamprecht, W., F. Stan, H. Weisser and F. Heinz,19741974pp: 1776-1778pp: 1776-1778Li, L., L.K. Zhang, Y.Z. Pang, C.S. Pan, Y.F. Qi, L. Chen, X. Wang, C.S. Tang and J. Zhang,200627527535Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall,1951193265275Moron, M.S., J.W. Depierre and B. Mannervik,19795826778Misra, H.P. and I. Fridovich, 197615681687Mohanty, I., D.S. Arya, A. Dinda, K.K. Talwar, S. Joshi and S.K. Gupta,2004Withania somnifera in experimentally induced myocardial infarction.]]>94184190Nakayama, H., X. Chen, C.P. Baines, R. Klevitsky and X. Zhang et al.,200711724312444Ohkawa, H., N. Ohishi and K. Yagi,197995351358Paglia, D.E. and W.N. Valentine,196770158169Pawar, R., C. Gopalakrishnan and K. Bhutani,2001Bacopa monniera as the superoxide inhibitor in polymorphonuclear cells.]]>67752754Rai, D., G. Bhatia, G. Palit, R. Pal, S. Singh and H. Singh,2003Bacopa monniera (Brahmi).]]>75823830Rajadurai, M. and P.S.M. Prince,2005Aegle marmelos extract and alpha-tocopherol on serum lipids, lipid peroxides and cardiac enzyme levels in rats with isoproterenol-induced myocardial infarction.]]>467881Rajadurai, M. and P.S.M. Prince,2007in vivo and in vitro study.]]>232216225Rona, G.,198517291306Rump, A.F., J. Schierholz, R. Rosen, K. Guttler and W. Klaus,200151964970Sairam, K., C.V. Rao, M.D. Babu and R.K. Goel,2001Bacopa monniera in gastric ulcer models.]]>8423430Sharma, M., K. Kishore, S.K. Gupta, S. Joshi and D.S. Arya,2001Ocimum sanctum in isoproterenol induced myocardial infarction in rats.]]>2257583Srivastava, S., B. Chandrasekar, Y. Gu, J. Luo and T. Hamid et al.,200774445455Tappia, P.S., T. Heta and N.S. Dhalla,20012+ transport. ]]>3778592Tripathi, Y.B., S. Chaurasia, E. Tripathi, A. Upadhyay and G.P. Dubey,1996Bacopa monniera Linn. as an antioxidant: Mechanism of action.]]>34523526Trivedi, C.J., R. Balaraman, J.B. Majithiya and S.B. Bothara,2006772532Yogeeta, S.K., H.R. Raghavendran, A. Gnanapragasam, R. Subhashini and T. Devaki,2006163160169