International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2007.334.340 Pergularia tomentosa L. (Asclepiadaceae)]]>HassanS. W.UmarR. A.LadanM. J.NyemikeP. WasaguR. S.U.M. LawalEbboA. A.4200734This study was aimed to assess the nutritive value, phytochemical constituents and antifungal activity of leaf, root and stem extracts of Pergularia tomentosa. Chemical composition of leaf, stem and root extracts of the plant were determined using standard methods. Aqueous and organic solvents extracts of the plant parts were screened for antifungal activity using agar dilution method. Phytochemicals detected in the leaf and stem extracts were alkaloids, cardiac glycosides, cyanogenic glycosides, saponins, flavonoids, tannins and anthraquinones. The roots contain trace amounts of cyanogenic glycosides, cardiac glycosides, saponins, tannins and anthraquinones. Mineral element composition of the plant showed higher amount of phosphorus and potassium in the root and stem and sodium, magnesium and calcium in the leaf extracts. All the plant parts used contain high percentages of carbohydrates and crude fibre ranging from 53.27±1.75 to 61.31±2.84% and 16.33±0.29 to 23.17±0.58%, respectively. Lipids (6.83±0.76%), ash (17.17±1.04%) and crude protein contents (6.39±0.17%) were higher in the leaf extracts while the stem was of higher moisture (10.67±0.76%) content. Hexane (HX), Petroleum Ether (PE) and chloroform (CHL) leaf, stem and root extracts were active against all the isolates tested with percentage inhibitions ranging from 41.90±5.63 to 97.52±0.28%. The organic solvent extracts demonstrated near complete inhibitions of the fungal isolates at 8.00 mg mL-1 while the aqueous (AQ) extracts of the plant parts inhibited the growth of the isolates at 27.17±7.79 to 97.45±0.21% with near complete inhibition of the tested isolates also at 8.00 mg mL-1. The results showed that the leaf, root and stem extracts of Pergularia tomentosa have potential nutritional and antifungal uses.]]>Abulude, F.O.,2001233639Adetuyi, A.O.,20042004AOAC,198013th Edn.,pp: 18-62pp: 18-62Cheesbrough, M.,1982Vol. 2,pp: 283-387pp: 283-387Cook, N.C. and S. Samman,199676676Cowan, M.M.,199912564582Dominguez, J.M. and J.J. Martin,1998Candida albicans.]]>4222792283Dzomeku, B.M., R.K. Bam, E. Abu-Kwarteng and A.A. Ankomah,20061187191El-Olemyl, M.M., F.J. Al-Muhtadi and A.A. Afifi,1994pp: 1-134pp: 1-134Favel, A., M.D. Steinmetz, P. Regli, E.V. Olivier, R. Elias and G. Balandsard,1994In vitro antifungal activity of triterpenoid saponins.]]>605053Fostel, J.M. and P.A. Lartey,200052532Gohar, A.A., M.M. El-Olemy, E. Abdel Sattar, M. El-Saaid and M. Niwa,2000Pergularia tomentosa.]]>6913191322Hamed, A.L., A. Plaza, M.L. Balestrieri, U.A. Mahel and I.V. Springuel et al.,2006Pergularia tomentosa and their proapoptotic activity in Kaposi's Sarcoma cells.]]>6913191322Hammiche, V. and K. Maiza,2006105358367Harborne, J.B.,19733rd Edn.,pp: 7-13, 60-89, 131-135, 186-188, 203, 279pp: 7-13, 60-89, 131-135, 186-188, 203, 279Hussein, H.I., D. AlRajhy and S.M. Hashem,1999Pergularia tomentosa (L.), methomyl and methlocarb, against land snails.]]>45211213Jimoh, F.O. and A.T. Oladiji,2005Piliostigma thonningii seeds: Proximate analysis, mineral composition and phytochemical screening.]]>414391442Lartey, P.A. and C.M. Moehle,19971997pp: 151-160pp: 151-160Lewis, W.H. and M.P. Elvin-Lewis,1995821624Morris, K.S. and K. Aziz,1976Rhamnus frangular L.]]>39223224Musa, O.,2005Capparis ovata Desf. Var. Canescens (Coss.) Heywood growing wild in Turkey.]]>8405407Oyagade, J.O., O.O. Awotoye, T.J. Adewumi and H.T. Thorpe,199911193197Oyeleke, O.A.,1984Oyenuga, V.A. and B.L. Fetuga,1975Citrullus vulgaris schrad).]]>26843846Samuel, A.L., V.J. Temple and O. Ladeji,1997Balanites aegyptica.]]>85763Scalbert, A.,19913038753883Shabana, M.M., Y.W. Mirhom, A.A. Genenah, E.A. Aboutabl and H.A. Amer,199044389394Shale, T.L., W.A. Stirk and J. van Staden,199967347354Shelton, R.M.,1991Aloe vera: Its chemical and therapeutic properties.]]>30679683Springfield, E.P. and F. Weitz,2006Carpobrotus mellei L. base on antimicrobial activity and chemical profiling.]]>512891293Subramanian, S., D.S. Kumar, P. Arulselvan and G.P. Senthilkumar,2006In vitro antibacterial and antifungal activities of ethanolic extract of aloe vera leaf gel.]]>1348355Talwar, G.P., L.M. Strivastava and K.D. Mudgil,19892nd Edn.,Trease, G.E. and W.C. Evans,197811th Edn.,pp: 530pp: 530Ueki, M. and M. Taniguchi,1997 sp.]]>5010521057Wall, M.E., M.M. Krinder, C.F. Krewson, C.R. Eddy, J.J. Wilaman, S. Correll and H.S. Gentry,19543631717WHO,19981998Yawas, D.S. and A.I. Obi,2001912Zacchino, A.S., N.S. Lopez, D.G. Pezzenati, L.R. Furlan and D.R. Enriz et al.,1999In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.]]>6213531357