International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2007.210.218Galega purpurea Root]]>GuptaM. MazumdarU. K.GomathiP. 3200733The present study was designed to investigate anti-inflammatory and antinociceptive activities of Galega purpurea root. In this study both acute and chronic inflammation models were used to evaluate the anti-inflammatory activity of the extract and four different animal models were employed to investigate the antinociceptive activity of the extract. In acute model carrageenan, dextran, histamine and serotonin models were used to induce inflammation in rat hind paw and cotton pellet-induced granuloma method was used for chronic inflammation model. Acetic acid-induced writhing, method hot plate method, tail flick response and tail immersion methods were used to evaluate the antinociceptive effect of the extract. The methanol extract of Galega purpurea root exhibited significant, dose-dependent activity on the tested experimental animal models. Also the extract significantly reduced the acetic acid-induced abdominal contractions and the increased reaction time of mice in hot plate method, tail flick response and tail immersion method. This study has shown that the methanol extract from the roots of Galega purpurea does possess significant antiinflammatory and antinociceptive activity in laboratory animals at the doses tested and the results were comparable to those observed for the standard drugs indomethacin, acetyl salicylic acid and morphine.]]>Almeida, R.N., R.N. Almeida, D.S. Navarro and J.M. Barbosa-Filho,20018310322Bentley, G.A., S.H. Newton and J. Starr,198173325332Bentley, G.A., S.H. Newton and J. Starr,198379125134Collier, H.O.J., L.C. Dinneen, C.A. Johnson and C. Schneider,196832295310D'Amour, F.E. and D.L. Smith,1941727479D'Arcy, P.F., E.M. Haward, R.W. Muggleton and S.B. Townsend,196012659665Deraedt, R., S. Jouquey, F. Delevallee and M. Flahaut,1980611724Dhara, A.K., V. Suba, T. Sen, S. Pal and A.K.N. Chaudhuri,2000Tragia involucrata Linn.]]>72265268Di Rosa, M., J.P. Ground and D.A. Willoughby,19711041529Di Rosa, M.,19741974pp: 829-839pp: 829-839Duke, J.A.,1992Fields, H.L.,19871987pp: 272pp: 272Flower, B.A., S. Moncada and J.R. Vane,19851985pp: 674-715pp: 674-715Franzotti, E.M., C.V.F. Santos, H.M.S.L. Rodrigues, R.H.V. Mourao, M.R. Andrade and A.R. Antoniolli,2000Sida cordifolia L. (Malva-branca).]]>72273278Garcia, M.D., M.A. Fernandez, A. Alvarez and M.T. Saenz,2004Pimenta racemosa var. ozua (Mirtaceae).]]>916973Gene, R.M., L. Segura, T. Adzet, E. Marin and J. Iglesias,1998Heterotheca inuloides: Anti-inflammatory and analgesic effects.]]>60157162Ghosh, M.N., R.H. Banerjie and S.K. Mukherji,196371721Hiruma-Lima, C.A., J.S. Gracioso, E.J.B. Bighetti, L. Germonsen Robineou and A.R.M. Souza Brito,2000Boerhaavia diffusa L. (Nyctaginaceae) markedly reduces pain in mice.]]>71267274Hollander, C., M. Nystrom, S. Janciauskiene and U. Westin,2003in vitro.]]>31422Levini, J.D., W. Lau, G. Kwait and E.J. Goetzl,1984225743745Lo, T.N., A.P. Almeida and M.A. Beavan,1982221261267Nadkarni, A.K.,19761st Edn.,Olajide, O.A., J.M. Makinde and S.O. Awe,1999Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice.]]>66113117Omisore, N.O.A., C.O. Adewunmi, E.O. Iwalewa, B.T. Ngadjui, J. Watchueng, B.M. Abegaz and J.A.O. Ojewole,2004Dorstenia barteri (Moraceae) leaf and twig extracts in mice.]]>95712Palanichamy, S. and S. Nagarajan,1990Cassia alata leaf extract and kaempferol 3-O-sophoroside.]]>297378Plummer, J.L., P.L. Cmielewski, G.K. Gourlay, H. Owen and M. Cousins,1991267887Suleyman, H., L.O. Demirezer, A. Kuruuzum, Z.N. Banoglu, F. Goccer, G. Ozbakir and A. Gepdiremen,1991Rumex patientia L. roots.]]>65141148Swingle, K.F., S. Sanchez, L. Rodriguez, O. Pol and M.M. Puig,200060121127Thompson, W.R. and C.S. Weil,195285154Trease, G.E.,198312th Edn.,Pages: 812Pages: 812Turner, R.A.,1965pp: 100-102pp: 100-102Vinegar, R., W. Schreiber and R. Hugo,196916696103Vinegar, R., J.F. Truax, J.L. Selph, P.R. Johnston, A.L. Venable and K.K. McKenzie,198746118126Winter, C.A. and C.C. Porter,195746515519Winter, C.A., E.A. Risley and G.W. Nuss,1962111544547Taesotikul, T., A. Panthong, D. Kanjanapothi, R. Verpoorte and J.J.C. Scheffer,2003Tabernaemontana pandacaqui poir.]]>843135