International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2007.195.197HadiMaleki HassanMalekinejad 2200732Phenoxybenzamine (POB) as an irreversible α-adrenoceptor antagonist was used to evaluate any possible therapeutic effects on stress-induced disorders in defecation in rats. In this study restriction stress was conducted on control and treated groups of rats with 0.1 and 1% of POB in a 2 mg kg-1 dose. After performing of restriction and drug administration, the frequency and weight of dropped faecal pellets were determined between 0-6, 6-12 and 12-24 h. The observed data showed no significant differences between control and treated animals (p>0.05). Present data suggest that although no significant differences have been observed in this trial but it could not be excluded due to other pharmacokinetic factors of phenoxybenzamine, which requires further studies to be conducted to elucidate more detail about it.]]>Banner, S.E., M.I. Smith, D. Bywater, L.M. Gaster and G.J. Sanger,19964 receptor activation in the mouse.]]>308181186Bellinger, L.L., F.E. Williams, J. Lucente, J. Pavelka, K.D. Dixon and D.W. Gietzen,2005812431Bodenstein, J., D.P. Venter and C.B. Brink,2005314891905Cable, D.G., J.A. Caccitolo, P.J. Pearson, T. O'Brien and C.J. Mullany et al.,199898II.15II.22Eglen, R.M., H. Reddy and N. Watson,19942613571368Fischer, J.R., I.F. Lane and A.E. Cribb,2003673038Hood, D.M., K.A. Stephens and M.J. Bowen,1982180758758Marks, S.L., I.M. Straeter-Knowlen, M. Moore, R. Speth, M. Rishniw and G.G. Knowlen,19965714971500Miyata, K., H. Ito and S. Fukudo,1998274G827G827Range, H., M.M. Dale, J.M. Ritter and P. Moore,20035th Edn.,pp: 173pp: 173Sanger, G.J., S.E. Banner, M.I. Smith and K.A. Wardle,199810271271Sanger, G.J., M. Yoshida, M. Yahyah and K. Kitazumi,2000130706712Taggart, D.P., M. Dipp, S. Mussa and P.C. Nye,2000120815817Tanaka, Y. and K. Nakayama,1998101200208Te, A.E.,200224851861Van der Graaf, P.H. and W.B. Stam,199941117125Von Euler, U.S. and P. Hedqvist,197492283283