International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2007.187.190In vivo Antioxidant Potentials of Rosa Damascene Petal Extract from Guilan, Iran, Comparable to α-tocopherol]]>ShahriariSanaz YasaNarguess MohammadiradAzadeh KhorasaniReza AbdollahiMohammad 2200732Rosa damascena Mill, (Rosaceae) is a widely cultivated ornamental plant. Several therapeutic effects including calmative, antianxiety, laxative and antispasmodic have been described for the flower of R. damascena. The petals of R. damascena are specially used as cardiotonic by the people of Guilan province. In this study antioxidant potential of R. damascena petals were determined by FRAP test and its ability to inhibit lipid peroxidation was determined by TBARS test in rat. In vivo examination was performed by oral administration of ethanol extract of R. damascena petals at doses of 50, 75, 100 and 200 mg/kg/day for 10 days which compared to vitamin E (10 mg/kg/day) and control groups. In vivo evaluation of antioxidant effects of R. damascene with these two methods showed that the extract of R. damascena has a high ability to inhibit lipid peroxidation and has a high antioxidant power with all doses comparing to control (p<0.001). The highest activity was observed with the dose of 200 mg/kg/day. This preliminary study indicates the interesting anti oxidative stress activity of R. damascena, which is comparable to the known antioxidant compound, alpha-tocopherol. R. damascena can be considered as a medicinal source for the treatment and prevention of many free radicals related diseases.]]>Abdollahi, M., A. Ranjbar, S. Shadnia, S. Nikfar and A. Rezaie,200410RA141RA147Benzie, I.F.F. and J.J. Strain,19962397076Chang, W.S., Y.J. Lee, F.J. Lu and H.C. Chiang,19931321652170Yuting, C., Z. Rongliang, J. Zhongjian and J. Yong,199091921DeWhalley, C.V., J.F. Rankin and S.M. Rankin,19933917431750Ghafari, H., N. Yasa, A. Mohammadirad, G. Dehghan and M.J. Zamani et al.,2006Ziziphora clinopoides of acetic acid-induced toxic bowel inflammation through reduction of cellular lipid peroxidation and myeloperoxidase activity.]]>25325332Kirov, M. and A. Bainova,199813115Mehdipour, S., N. Yasa, G. Dehghan, R. Khorasani, A. Mohammadirad, R. Rahimi and M. Abdollahi,2006Carica papaya juice in vitro and in vivo are comparable to alpha-tocopherol.]]>20591594Miller, A.L.,19961103111Ozkan, G., O. Sagdic, N.G. Baydar and H. Baydar,2004Rosa damascena flower extract.]]>10277281Penckofer, S., D. Schwertz and K. Flerczak,2002166885Ravanel, P., M. Tissuet and R. Douce,198269375378Saija, A., M. Scalese, M. Lanza, D. Marzullo, F. Bonina and F. Castelli,199519481486Satho, K.,1978903743Schiieber, A., K. Mihalev, N. Berardini, P. Mollov and R. Carle,2005Rosa damascena Mill.]]>60379384Skaper, S.D., M. Fabris, V. Ferrari, M., Dalle Carbonare and A. Leon,199722669678Tisserand, R. and T. Balacs,1995pp: 204-210pp: 204-210Nakhai, L.A., A. Mohammadirad, N. Yasa, B. Minaie and N. Nikfar et al.,2007Zataria multiflora Boiss. in experimental model of mouse inflammatory bowel disease.]]>44350Ghazanfari, G., B. Minaie, N. Yasa, L.A. Nakhai and A. Mohammadirad et al.,2006Satureja khuzestanica jamzad essential oil on the mouse model of inflammatory bowel diseases.]]>16365372