International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2007.175.178Diarun plus) on the Glycemic Status Modified by Physiological Means in Non-diabetic Mice and Rats]]>SenthilvelG. AustinAnoop JegadeesanM. ThirugnanasambanthamP. NarayananN. ViswanathanS. 2200732Diarun plus a polyherbal formulation containing herbal ingredients of folkloric Antidiabetic effect, was investigated for its effect on glycemic status in rats and mice. In contrast to conventional chemical induced diabetic animal models, changes in glycemic states were induced by physiological maneuvers. Results revealed that in euglycemic animals Diarun plus elicited little change (-10 to +10%) insignificantly. In food deprivation/swim exercise induced hypoglycemia, Diarun plus reduced the degree of hypoglycemia in both rats and mice (From 38 to 27% in rats and 45 to 32% in mice). Similarly, the marked hyperglycemia induced by dextrose (70% in rats and 95% in mice) was reduced markedly to 8 and 25% , respectively. The findings of the present study suggests that the ingredients of Diarun plus have the unique property of maintaining near euglycemic state irrespective of the altered glycemic state and that have no significant effect in euglycemic condition.]]>Abdel-Barry, J.A., I.A. Abdel-Hassan and M.H.H. Al-Hakiem,1997Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats.]]>58149155Anonymous,1976Vol. 1,pp: 147pp: 147Anonymous,2001Vol. 2,pp: 264pp: 264Anonymous,2002Diarun plus, a polyherbal formulation on physiologically modified glycemic and insulinemic status in mice.]]>2002Chopra, R., S.L. Nayar and I.C. Chopra,19561st Edn.,Jose, J.K. and R. Kuttan,1995Emblica officinalis.]]>196370Karunanayake, E.H., J. Welihinda, S.R. Sirirnanne and G.S. Adorai,198411223231Kohli, K.R. and R.H. Singh,1993Eugenia jambolana) in non-insulin dependent diabetes mellitus.]]>148997Nadkarni, K.M.,1954Vol. 1,Mohan, V., S. Shanthirani, P. Deepa, G. Premalatha and N.G. Sastry et al.,2001184280287Rajendran, N.N., P. Thirugnanasambantham, S. Parvathavarthini, S. Viswanathan and S. Ramaswamy,20013910091016Sauvaire, Y., C. Broca, P. Petit, M. Jacob, Y. Baissac, M. Manteghetti, M. Roye and G. Ribes,1996/19971996/1997Senthilvel, G., M. Jegadeesan, A. Austin, P. Thirugnanasambantham, M. Balasubramanian and E. Mayisvren,2004Diarun Plus) in the management of Type 2 Diabetes mellitus in Indian patients.]]>245762Senthilvel, G., A. Austin, P. Thirugnanasambantham, E. Mayisvren, M. Balasubramanian and M. Jegadeesan,2006Diarun plus) on streptozotocin induced experimental diabetes.]]>18892Yoshikawa, M., T. Morikawa, H. Matsuda, G. Tanabe and O. Muraoka,2002Salacia reticulata.]]>1015471554