International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2006.316.319IranparvarM. BazarganiH. Sadeghi-KhodamoradzadehM. 3200623The aim of the present study was to test Diamicron`s effectiveness in a group of Iranian patients. In a clinical trial study, 40 diabetic patients which their hyperglycemia was not controlled with diet and exercise were enrolled to take Diamicron MR for a 12 weeks period and their Fasting Plasma Glucose (FPG) and HbA1c measured during treatment. Data were analyzed by SPSS11 statistical package. Repeated measures ANOVA and Paired t tests were used to analyze data . Twenty four persons (60%) were males and 16 of them (40%) were females. The mean for age was 48.8±13.2 (SD) years. FPG in patients before starting drug treatment had a mean of 236.65±75 mg dL-1. Mean of FPG for second week after start of treatment was 180±65 mg dL-1. It was 152±61 mg dL-1 on 4th week and 136±35 mg dL-1 on 8th week. Mean of FPG on 12th weeks was 131±40 mg dL-1. HbA1c was checked both at the beginning of treatment and at the 12th week. Its mean was 11.1±1.9 at the beginning and it was 8.6±1.6 after 12 weeks. The decrease in FPG and HbA1c during the treatment period compared to pretreatment FPG was statistically significant (p<0.01). Diamicron MR was effective in controlling hyperglycemia with a good compliance and less complications in Iranian patients.]]>Azizi, F.,200248084Buse, J.B.,1999226570Collier, A., H.H. Watson, A.W. Patrick, C.A. Ludlam and B.F. Clarke,198915420425Defronzora,20001337374Drouin, P.,200014185191Guillausseau, P.J. and W. Greb,200127133137Harrower, A.D.,19859676680Inzucchi, S.E.,2002287360372Jennings, P.E., N.A. Scott, A.R. Saniabadi and J.J. Belch,1992413639Noury, J. and A. Nandeuil,199117209212Paes, A.H., A. Bakker and C.J. Soe-Agnie,19972015121517Prospective Diabetes Study Group,1998352837853Pullar, T., A.J. Birtwell, P.G. Wiles, A. Hay and M.P. Feely,198844540545Tessier, D., K. Dawson, J.P. Tetrault, G. Bravo and G.S. Meneilly,199411974980Tessier, D., P. Maheux, A. Khalil and T. Fulop,199948897903DCCT Research Group,1993329977986