International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2006.293.297HighleyM. S.HarperB. HarperP. G.DumezH. GuetensG. BoeckG. DePrenenH. SchrijversD. MaesR. A.A.BruijnE.A. De3200623The purpose of this study was to investigate the pharmacokinetics of mitomycin C when administered with ifosfamide and cisplatin as part of the mitomycin C, ifosfamide and cisplatin (MIC) regimen. Eleven patients with advanced non-small cell lung cancer, aged 49-73 years, were treated with mitomycin C (6 mg m-2), ifosfamide and cisplatin. Mitomycin C concentrations in plasma and erythrocytes were determined using HPLC with UV absorbance detection at 360 nm. The plasma β half life of mitomycin C was 44 min and the clearance 16.38 L h-1 m-2. A mean erythrocyte/plasma ratio of 0.87 (SD±0.35) was obtained. At low plasma concentrations, mitomycin C was undetectable in the erythrocyte. The mean plasma mitomycin C concentration when this occurred was 50 ng mL-1 (SD±35). The plasma pharmacokinetics of mitomycin C in the MIC regimen are consistent with the pharmacokinetic data obtained as a single agent, or as a component of other chemotherapy regimens. Mitomycin C is taken up into erythrocytes and is detectable within these cells for two hs following injection. The erythrocyte may act as a transporter of this compound in the circulation.]]>Buice, R.G., H.B. Niell, P. Sidhu and B.J. Gurley,19841314Cullen, M.H., R. Joshi, A.D. Chetiyawardana and C.M. Woodroffe,198858359361Den Hartigh, J., J.G. McVie, W.J. van Oort and H.M. Pinedo,19834350175021Den Hartigh, J., G. Voortman, W.J. van Oort, H.M. Pinedo and H. Weenen,198321515Dennis, I.F., J.R.S. Ramsey, P. Workman and N.M. Bleehen,1993326772Driessen, O., M.S. Highley, P.G. Harper, R.A.A. Maes and E.A. de Bruijn,199427195196Fisher, J.F. and R.A. Olsen,198221240243Fracasso, P.M. and A.C. Sartorelli,19864639393944Holford, N.,1990Korkmaz, O. and M. Korkmaz,199769167174Lankelma, J., M. Stuurman, J. van Hoogenhuijze, A. van Bochove, J.B. Vermorken, J. Verweij and H.M. Pinedo,198824175180Momerency, G., K. van Cauwenberghe, M.S. Highley, P.G. Harper, A.T. van Oosterom and E.A. de Bruijn,199685262265Reich, S.D.,19791979pp: 243-250pp: 243-250Sarna, G.P., R. Champlin, R. Wells and R.P. Gale,198266277282Schilcher, R.B., J.D. Young, V. Ratanatharathorn, C. Karanes and L.H. Baker,198413186190Schrijvers, D., M. Highley, E. de Bruyn, A.T. van Oosterom and J.B. Vermorken,199910147153Schwartz, H.S. and F.S. Philips,1961133335342Tjaden, U.R., J.P. Langenberg, K. Ensing, W.P. van Bennekom, E.A. de Bruijn and A.T. van Oosterom,1982232355367Van Hazel, G.A. and J.S. Kovach,19828189192Van Hazel, G.A., M. Scott, J. Rubin, C.G. Moertel, R.T. Eagan, M.J. O'Connell and J.S. Kovach,198367805810Verweij, J., M. Stuurman, J. de Vries and H.M. Pinedo,1986112283284