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Various clinical and in vitro studies have shown that nRTIs are associated with mitochondrial dysfunction in different tissues, although the weight of evidence is limited in many cases. The heterogeneity in the tissues affected by the different drugs raises interesting questions and possible explanations include differential distribution or activation of these agents. This study gives an overview of the major recognised toxicities associated with nRTI use in Human Immunodeficiency syndrome (HIV) therapy and evidence for mitochondrial dysfunction in these complications.]]>Lewis, W., J.F. Simpson and R.R. Meyer,199474344348Moyle, G.J.,200494547Moyle, G.J. and M. Sadler,199819481494Lopez, S., O. Miro, E. Martinez and E. Pedrol,200494755Lecrenier, N. and F. Foury,20002463748Pinti, M., L. Troiano, M. Nasi and R. 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