International Journal of Osteoporosis and Metabolic Disorders1994-54422077-2157Asian Network for Scientific Information10.3923/ijom.2008.8.15MoradzadehK. LarijaniB. KeshtkarA.A. Hossein-NezhadA. RajabianR. NabipourI. OmraniG.H. BahramiA. GooyaM.M. DelavariA. 1200811There is no agreement about normal level of vitamin D and its deficiency
stages. For finding normative value of Vitamin D and evaluating the state
of vitamin D level in Iranian population we revised the data that was
collected in Iranian national Multi-center Osteoporosis Study (IMOS).
We chose 5 cities with different climates; individuals were selected by
random cluster sampling. Healthy people aged 20-69 were entered into the
study and serum vitamin D and PTH levels were measured. We stratified
subjects based on their vitamin D levels in 7 groups and compared mean
PTH levels of adjacent groups. We evaluated 5329 blood samples for vitamin
D and PTH and found three steps of PTH elevation with decreasing vitamin
D levels for women (40, 25 and 12 nmol L-1) and two (35 and
25 nmol L-1) for men. We use these values as cutoff levels
for definition of normal, mild, moderate and severe vitamin D deficiency
states. Based on these cutoffs, prevalence of all stages of vitamin D
deficiency was unexpectedly high in all cities. Vitamin D deficiency state
was seen in 75.1% of women and 72.1% of men. The high prevalence of vitamin
D deficiency in Iran is similar to the results of other studies in Middle
East area and indicates a need for a careful search for a determination
of cause and need for regular fortification program. ]]>Alagol, F., Y. Shihadeh and H. Boztepe, S. Yarman, H. Azizlerli and Ö. Sandalci,200023173177Awumey, E.M., D.A. Mitra and B.W. Hollis,199883169173Azizi, F., F. Rais-Zadeh and A. Mir Said Ghazi,20004291303Brown, A.J., A. Dusso and E. Slatopolsky,1999277F157F175Burnard, B., D. Sloutskis and F. Gianoli,199056537542Chapuy, M.C., M.E. Arlot, F. Duboeuf, J. Brun and B. Crouzet et al.,199232716371642Chapuy, M.C., P. Preziosi and M. Maamer,19977439443Dawodu, A., M. Agarwal, M. Hossain, J. Kochiyil and R. Zayed,2003142169173Du, X., H. Greenfield, D.R. Fraser, K. Ge, A. Trube and Y. Wang,200174494500Goswami, R., N. Gupta, D. Goswami, R.K. Marwaha, N. Tandon and N. Kochupillai,200072472475Hashemipour, S., B. Larijani and H. Adibi, H. Javadi and E. Sedaghat et al.,200443838Himmelstein, S., T.L. Clemens, A. Rubin, R. Lindsay and D. Vitamin,19902D.]]>52701706Holick, M.F., J.A. MacLaughlin and S.H. Doppelt,19813 photosynthesis in man: Skin pigment is not an essential regulator.]]>11590593Holick, M.F.,200298798Kinyamu, H.K., J.C. Gallagher and K.E. Balhorn,199765790797Lips, P., A. Wiersinga and F.C. Ginkel van,198867644650Lips, P.,200489-90611614MacLaughlin, J.A., R.R. Anderson and M.F. Holick,19823 and its photoisomers in human skin.]]>21610011003Omdahl, J.L., P.J. Garry and L.A. Hunsaker,19823612251232Ooms, M.E., P. Lips and J.C. Roos,19951011771184Sedrani, S.H., A.W. Elidrissy and K.M. El-Arabi,198338129132Sedrani, S.H.,198428181185Taha, S.A., S.M. Dost and S.H. Sedrani,198418739741Thomas, M.K., D.M. Lloyd-Jones and R.I. Thadhani,1998338777783Vander, R.P., M.R. Wielen Lowik and H. Vanden Berg,1995346207210