International Journal of Dairy Science1811-97431811-9751Asian Network for Scientific Information10.3923/ijds.2022.41.53MalikBurhanudin Apri AstutiDewi JayanegaraAnuraga RahminiwatiMin 22022172Leech has been used as a medical device in health therapy all over the world. Leech saliva contains many active compounds which have antioxidant, antimicrobial and anticoagulant properties and bring health benefits. On the other hand, mastitis in dairy animals is an important disease-causing great economic loss. Control of this disease can be done through good animal husbandry practice and a nutritional approach. Mineral and vitamin supplementations are commonly done to maintain the immune system. Antioxidant supplementation plays an important role in eliminating free radicals significantly found in animals with mastitis. Antibiotic administration is done to eliminate bacteria causing mastitis. 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