International Journal of Dairy Science1811-97431811-9751Asian Network for Scientific Information10.3923/ijds.2021.29.40M. El-MesseryTamer M. El-SaidMarwa SalamaHeba H. Mostafa MohammedDina RosGaspar 12021161Background and Objective: Mango peel is an excellent source of bioactive compounds especially Phenolic Compounds (PC). Due to the difficulty of adding the mango peel to food products as a solution we evaluated the feasibility of encapsulating a phenolic-rich extract from mango peel (MPPE) then added to milk beverage and the therapeutic effectiveness in protecting against oxidative stress was investigated. Materials and Methods: The characterization of MPPE microcapsules has been conducted by Scanning Electron Microscopy (SEM) and Encapsulation Efficiency (EE). The MPPE microcapsules were added in different proportions to the milk (1, 2 and 3%), physicochemical properties and the viscosity were evaluated during 14 days of cold storage. In vitro simulation digestion process (oral, gastric and intestinal phase) was evaluated for the total phenolic and flavonoid content (TPC and TFC) and antioxidant activity for both Mango Peel Phenolic Extract (MPPE) microcapsules and milk beverage supplemented with MPPE microcapsules. The milk beverage supplemented with microcapsules was investigated against oxidative stress using CCl4 injected rats. Results: The physicochemical properties of the milk beverage supplemented with microcapsule were not significantly affected compared to the control sample. Furthermore, TPC, TFC and antioxidant activity values were increased significantly (2-3 times) at the end of the simulation digestive process for both MPPE microcapsules and milk beverage supplemented with MPPE microcapsules each individually. In vivo experiment, the total antioxidant and catalase levels were increased and the lipid peroxide, Alanine Transaminase (ALT), Aspartate Transaminase (AST) and Alkaline Phosphatase (ALP) activities were decreased when used milk beverage supplemented with MPPE microcapsules. Conclusion: These results demonstrated that MPPE microcapsules rich in bioactive components can be used as a chemo-preventive agent against oxidative stress disorders in experimental rats.]]>Corbo, M.R., A. Bevilacqua, L. Petruzzi, F.P. Casanova and M. Sinigaglia,20141311921206Ivanov, G.Y. and M.R. Dimitrova,201918530537Salama, H., M. Elsaid, S.A. Hamid, S. Abozed and M. Mounier,20206338793890Singh, V.P., V. Pathak and K.V. Akhilesh,20127266277Johnson, R.K., C. Frary and M.Q. Wang,2002102853856Finley, J.W.,20059510751096Ajila, C.M., K.A. Naidu, S.G. Bhat and U.J.S. Prasada Rao,2007105982988Jimenez-Lopez, C., M. Fraga-Corral, M. Carpena, P. García-Oliveira and J. Echave et al.,20201148534877Campos, D.A., R. Gómez-García, A.A. Vilas-Boas, A.R. Madureira and M.M. Pintado,20202020Ajila, C.M. and U.P. Rao,20135444450Kim, H., J.Y. Moon, H. Kim, D.S. Lee and H. Cho et al.,2010Mangifera indica L.) flesh and peel.]]>121429436Macías-Cortés, E., J.A. Gallegos-Infante, N.E. Rocha-Guzmán, M.R. Moreno-Jiménez, L. Medina-Torres and R.F. González-Laredo,202019491521Farrag, A., T.M. El-Messery, M.M. El-Said, T.N. Soliman and H.M.F. El-Din,201818373380El-Messery, T.M., M.M. El-Said, E. Demircan and B. Ozu00e7elik,2019182534Rezaei, A., M. Fathi and S.M. Jafari,201988146162Prasad, S., N. Kalra, M. Singh and Y. Shukla,200810313318Nikoo, A.M., R. Kadkhodaee, B. Ghorani, H. Razzaq and N. Tucker,2018116208216Hogan, S.A., B.F. McNamee, E.D. O-Riordan and M. O-Sullivan,200111137144Bule, M.V., R.S. Singhal and J.F. Kennedy,20108212901296Tian, S., K. Nakamura and H. Kayahara,20045248084813Ades, H., E. Kesselman, Y. Ungar and E. Shimoni,201245277288de Barros Fernandes, R.V., D.A. Botrel, E.K. Silva, S.V. Borges and C.R. de Oliveira et al.,2016153133142Naczk, M. and F. Shahidi,198931159164Leong, L.P. and G. Shui,2002766975Djeridane, A., M. Yousfi, B. Nadjemi, D. Boutassouna, P. Stocker and N. Vidal,200697654660Benzie, I.F.F. and J.J. Strain,19962397076Ling, E.R.,195710166166Krisnaningsih, A.T., P. Purwadi, H. Evanuarini and D. Rosyidi,2019Colocasia esculenta (L.) schott) starch as stabilizer.]]>7547554McDougall, G.J., P. Dobson, P. Smith, A. Blake and D. Stewart,2005in vitro digestion system.]]>5358965904Ezzat, A., A.O. Abdelhamid, M.K. El Awady, A.S.A. El Azeem and D.M. Mohammed,201795571576Velderrain-Rodríguez, G., H. Torres-Moreno, M. Villegas-Ochoa, J. Ayala-Zavala, R. Robles-Zepeda, A. Wall-Medrano and G. González-Aguilar,20182018El-Messery, T.M., U. Altuntas, G. Altin and B. Özçelik,2020In vitro bioaccessibility and oxidative stability of krill oil nanoemulsion system.]]>2020Tonon, R.V., C.R.F. Grosso and M.D. Hubinger,201144282289El-Messery, T.M., M.M. El-Said, N.M. Shahein, H.M.F. El-Din and A. Farrag,201922231238Eratte, D., B. Wang, K. Dowling, C.J. Barrow and B.P. Adhikari,2014527432750Salama, H.H., S.M. Abdelhamid and N.S. Abd-Rabou,202016661670Hassan, M., B.N. Dar, S.A. Rather, R. Akhter and A.B. Huda,201523239Saura-Calixto, F., J. Serrano and I. Goñi,2007101492501Ortega, N., A. Macia, M.P. Romero, J. Reguant and M.J. Motilva,2011in-vitro digestion model.]]>1246571Wooton-Beard, P.C., A. Moran and L. Ryan,2011in vitro digestion measured by FRAP, DPPH, ABTS and folin-ciocalteu methods.]]>44217221Rice-Evans, C.A., N.J. Miller and G. Paganga,199620933956Correa-Betanzo, J., E. Allen-Vercoe, J. McDonald, K. Schroeter, M. Corredig and G. Paliyath,2014Vaccinium angustifolium) polyphenols during simulated in vitro gastrointestinal digestion.]]>165522531Chen, G.L., S.G. Chen, F. Chen, Y.Q. Xie and M.D. Han et al.,2016in vitro digestion.]]>20317331Li, S., H.Y. Tan, N. Wang, Z.J. Zhang, L. Lao, C.W. Wong and Y. Feng,2015162608726124Nordlie, R.C., J.D. Foster and A.J. Lange,199919379406Robinson, M.W., C. Harmon and C. O’Farrelly,201613267276Weber, L.W.D., M. Boll and A. Stampfl,200333105136Yao, H.T., S.Y. Huang and M.T. Chiang,20084615251534Halliwell, B.,199755S44S49Noriega, G.O., J.O. Ossola, M.L. Tomaro and A.M. del C. Batlle,200032983991Lee, N.H., C.S. Seo, H.Y. Lee, D.Y. Jung and J.K. Lee et al.,2011Cornus officinalis against acetaminophen-induced hepatotoxicity in mice.]]>201218Gamal El-Din, A.M., A.M. Mostafa, O.A. Al-Shabanah, A.M. Al-Bekairi and M.N. Nagi,200348631635Sabina, E.P., S.J. Pragasam, S. Kumar and M. Rasool,2011912641269Adeneye, A.A., O. Awodele, S.A. Aiyeola and A.S. Benebo,2015Mangifera indica on carbon tetrachloride-induced hepatotoxicity in rats.]]>5106115Yang, J., Y. Li, F. Wang and C. Wu,20104-induced acute liver damage in mice.]]>5865256531Ahmad, S.T., W. Arjumand, S. Nafees, A. Seth, N. Ali, S. Rashid and S. Sultana,2012208149161Shankar, N.L.G., R. Manavalan, D. Venkappayya and C.D. Raj,2008Commiphora berryi (Arn) Engl bark extract against CCl4-induced oxidative damage in rats.]]>4631823185Huo, H.Z., B. Wang, Y.K. Liang, Y.Y. Bao and Y. Gu,20114-induced oxidative damage in rats.]]>1265296543