International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2018.92.99ArisantyDessy Yanwirasti JamsariJamsari HarahapWirsma A. KhambriDaan 22018142Background and Objective: miR-10b is one of oncogenic miRNA first described in promoting metastases in Breast Cancer. The aim of the study was to investigate the expression of miR-10b and the expression of metastases-induced genes in BC (BC) and fibroadenoma (FA) in West Sumatra. Materials and Method: LNATM primer enhancer set was used to identify the miR-10b expression as a relative quantification. miR-16 was used as an endogenous control with a relative median expression of miR-10b at 2ΔΔCt. The expression of metastases-related genes was performed by an absolute quantification method. Results: The statistical differences between miR-10b and the expression of genes were determined by t-student test to interpret the expression of BC and FA tissue (p<0.005). The expression of miR-10b in BC was lower than FA (endogenous control). Relative median of miR-10b expression in BC was 8.51 times lower than FA. Low expression of miR-10b in BC was associated with tissue grading. The expression of metastases-related gene; RhoC, TIMP2 and MMP2 were lower in BC than FA. miR-10b expression differed between BC and FA. Conclusion: RhoC, TIMP2 and MMP2 expression caused cancer cell whether to be metastasized or not. miR-10b is a potential marker to predict BC cell which start to be aggressive.]]>Torre, L.A., F. Bray, R.L. Siegel, J. Ferlay, J. Lortet-Tieulent and A. Jemal,20156587108IARC.,20122012Harahap, W.A.,20142014Lee, R.C., R.L. Feinbaum and V. Ambros,1993C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.]]>75843854Wang, F., Z. Zheng, J. Guo and X. Ding,2010119586593Lowery, A.J., N. Miller, A. Devaney, R.E. McNeill and P.A. Davoren et al.,2009neu receptor status in breast cancer.]]>2009Lu, J., G. Getz, E.A. Miska, E. Alvarez-Saavedra and J. Lamb et al.,2005435834838Blenkiron, C., L.D. Goldstein, N.P. Thorne, I. Spiteri and S.F. Chin et al.,20072007Ma, L., J. Teruya-Feldstein and R.A. Weinberg,2007449682688Gee, H.E., C. Camps, F.M. Buffa, S. Colella and H. Sheldon et al.,2008455E8E9Lund, A.H.,201017209214Slack, F.J. and J.B. Weidhaas,200835927202722Iorio, M.V. and C.M. Croce,20124143159Schickel, R., B. Boyerinas, S.M. Park and M.E. Peter,20082759595974Xie, S., M. Zhu, G. Lv, Y. Geng, G. Chen, J. Ma and G. Wang,2013in vitro and in nude mouse xenografts.]]>2013Xie, S.L., M.G. Zhu, G.F. Chen, G.Y. Wang and G.Y. Lv,20151250775085Liu, B.L., K.X. Sun, Z.H. Zong, S. Chen and Y. Zhao,2016766496664Sang, X.B., Z.H. Zong, L.L. Wang, D.D. Wu, S. Chen, B.L. Liu and Y. Zhao,201781477714793Gou, W.F., Y. Zhao, H. Lu, X.F. Yang and Y.L. Xiu et al.,20142014Van Golen, K.L., L. Bao, M.M. DiVito, Z. Wu, G.C. Prendergast and S.D. Merajver,20021575583Van Golen, K.L., Z.F. Wu, X.T. Qiao, L.W. Bao and S.D. Merajver,20006058325838Horiuchi, A., T. Imai, C. Wang, S. Ohira, Y. Feng, T. Nikaido and I. Konishi,200383861870Zhang, Z.J. and S.L. Ma,201227903910Ikoma, T., T. Takahashi, S. Nagano, Y.M. Li and Y. Ohno et al.,20041011921200Liu, S.C., S.F. Yang, K.T. Yeh, C.M. Yeh and H.L. Chiouet al.,20063719296Xu, X., Y. Wang, Z. Chen, M.D. Sternlicht, M. Hidalgo and B. Steffensen,200565130136Scorilas, A., A. Karameris, N. Arnogiannaki, A. Ardavanis, P. Bassilopoulos, T. Trangas and M. Talieri,20018414881496Lemeshow, S. and J. David,1997Bertoli, G., C. Cava and I. Castiglioni,2015511221143O'Bryan, S., S. Dong, J.M. Mathis and S.K. Alahari,201772111Rakha, E.A., J.S. Reis-Filho, F. Baehner, D.J. Dabbs and T. Decker et al.,20102010Stevens, A., J. Lowe and I. Scott,20093rd Edn.,Frixa, T., S. Donzelli and G. Blandino,2015724662485Yanwirasti, W.A.H. and D. Arisanty,201720189196Biagioni, F., N.B. Ben-Moshe, G. Fontemaggi, V. Canu and F. Mori et al.,2012412141229Baffa, R., M. Fassan, S. Volinia, B. O'Hara and C.G. Liu et al.,2009219214221Singh, R. and Y.Y. Mo,201314201212Croset, M., D. Goehrig, A. Frackowiak, E. Bonnelye, S. Ansieau, A. Puisieux and P. Clezardin,20142918861899Ma, L., F. Reinhardt, E. Pan, J. Soutschek and B. Bhat et al.,201028341347Kitzing, T.M., Y. Wang, O. Pertz, J.W. Copeland and R. Grosse,20102924412448Wang, Y., Z. Li, X. Zhao, X. Zuo and Z. Peng,201612488494Jezierska, A. and T. Motyl,200915RA32RA40