International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2017.1.8AKT3, SDCCAG8 and SLC35F3 Genes at Chromosomal 1q42.2-44 Region in Non-small Cell Lung Cancer: Early and Prognostic Implications]]>KangJiun 12017131Background: Genomic alterations in the early stage of Non-Small Cell Lung Cancer (NSCLC) have a tight relationship with tumor initiation and potentially activate downstream pathways that are implicated in tumor progression. Methodology: In this study, the most salient and consistent finding was frequentcopy number gains (log2 ratio >0.25) at the long of chromosome 1, which occurred in 78.3% (18/23) of stage I/II NSCLC cases and the delineated minimal common region was 1q21.1-q44. More importantly, three distinct regions of amplifications in the 1q21.1-q44 region were detected in 17.4% (4/23) of the cases. Results: Among these amplified loci, the 1q44 locus comprises AKT3 are presentative oncogene. In addition, SDCCAG8 (1q44) and SLC35F3 (1q42.2) genes were identified as probable genetic targets within the amplicon (12.5%), which have not been previously considered to play a pathogenic role in NSCLCs. These findings suggested that genetic alterations on chromosome 1q are the first step in the initiation of the genomic instability contributing to early NSCLC development. Conclusion: The newly identified genes at the 1q42.2-q44 amplified chromosomal region might be of interest for further studies of the pathophysiology of the early stages of NSCLC and are indicated as potential therapeutic targets.]]>Langevin, S.M., R.A. Kratzke and K.T. Kelsey,20151657490Smythe, W.R.,20018318325Gumireddy, K., A. Li, D.H. Chang, Q. Liu and A.V. Kossenkov et al.,201561763717647Jiang, F., Z. Yin, N.P. Caraway, R. Li and R.L. Katz,20046623635Kang, J.U., S.H. Koo, K.C. Kwon, J.W. Park and J.M. Kim,2008TERT, is the most frequent genetic event in early stages of non-small cell lung cancer.]]>182111Varella-Garcia, M., R.M. Gemmill, S.H. Rabenhorst, A. Lotto, H.A. Drabkin, P.A. Archer and W.A. Franklin,19985847014707Hwang, K.T., W. Han, J. Cho, J.W. Lee and E. Ko et al.,20081518071815Park, J.J., J.K. Kang, S. Hong, E.R. Ryu, J.I. Kim, J.H. Lee and J.S. Seo,2008407139147Choi, Y.W., J.S. Choi, L.T. Zheng, Y.J. Lim and H.K. Yoon et al.,2007554351Choi, Y.W., S.M. Bae, Y.W. Kim, H.N. Lee and Y.W. Kim et al.,200717687696Pinkel, D., T. Straume and J.W. Gray,19868329342938Willenbrock, H. and J. Fridlyand,20052140844091Esposito, L., D. Conti, R. Ailavajhala, N. Khalil and A. Giordano,201011513518Hoffman, P.C., A.M. Mauer and E.E. Vokes,20005479485Hassanein, M., J.C. Callison, C. Callaway-Lane, M.C. Aldrich, E.L. Grogan and P.P. Massion,201259921006Forus, A., M.L. Larramendy, L.A. Meza-Zepeda, B. Bjerkehagen and L.H. Godager et al.,2001125100111Tai, A.L.S., W.S. Yan, Y. Fang, D. Xie, J.S.T. Sham and X.Y. Guan,2004119181927Wong, M.P., L.F. Fung, E. Wang, W.S. Chow and S.W. Chiu et al.,2003112631270Zhu, H., M.P. Wong and V. Tin,20144420682076Kagawa, N., M. Maruno, T. Suzuki, T. Hashiba, N. Hashimoto, S. Izumoto and T. Yoshimine,2006234147Hashimoto, K., N. Mori, T. Tamesa, T. Okada and S. Kawauchi et al.,200417617622Soengas, M.S. and S.W. Lowe,20031931383151Dobashi, Y., H. Tsubochi, H. Matsubara, J. Inoue, J. Inazawa, S. Endo and A. Ooi,2015106772781Roudi, R., Z. Madjd, M. Ebrahimi, A. Najafi, A. Korourian, A. Shariftabrizi and A. Samadikuchaksaraei,2016371184311859Werner, S., H. Chen, J. Butt, A. Michel and P. Knebel et al.,20162016Liu, Y., Y. Geng, K. Li, F. Wang and H. Zhou et al.,20123470474Insolera, R., W. Shao, R. Airik, F. Hildebrandt and S.H. Shi,201420805822Divers, J., N.D. Palmer, L. Lu, C.D. Langefeld and M.V. Rocco et al.,2014APOL1-associated nephropathy.]]>29587594Kumamoto, K., Y. Goto, K. Sekikawa, S. Takenoshita, N. Ishida, M. Kawakita and R. Kannagi,20016146204627Zang, X.L., W.Q. Han, F.P. Yang, K.D. Ji and J.G. Wang et al.,2016SLC35F3 gene with the risk of hypertension in a Chinese Han population.]]>2016Matsuyama, R., S. Togo, D. Shimizu, N. Momiyama and T. Ishikawa et al.,2006119406413Kang, J.U., S.H. Koo, K.C. Kwon and J.W. Park,2010DOCK8, DMRT1 and DMRT3 deletion at 9p24.3 in squamous cell carcinoma of the lung.]]>37327335Kang, J.,20159345350