International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2016.176.187Citrus paradisi Waste
Extract and Cisplatin-induced Cytotoxicity]]>AkunnaG.G. ObikiliE.N. AnyanwuG.E. EsomE.A. 3-42016123-4Background and Objective: One of the several side effects of cancer treatment remains cytotoxicity. The curative effect of aqueous zest
extract of Citrus paradisi on cisplatin-induced testicular degeneration was studied. Materials and Methods: Sixteen male Wistar rats
(10-12 weeks old) weighing 237-276 g were divided into four groups. The first group of rats served as control and were
treated orally with 2.5 mL kg1 b.wt day1, group B rats treated with single dose of 10 mg kg1 b.wt., group C and D rats were treated
with a single dose of 10 mg kg1 b.wt. of cisplatin and then treated orally with 10 and 40 mg kg1 b.wt. of aqueous zest extract
of Citrus paradisi for 8 weeks. Results: Results showed a significant (p<0.05) decrease in testis weight, testis volume, sperm count,
sperm motility and normal sperm morphology (p<0.01). Also, observed was marked degeneration and atrophied tubules with absence
of late stage germ cells evidenced by significant reduction in tubular diameter (p>0.01), perimeter (p>0.01), length (p>0.001) and
width (p>0.05) in germinal epithelia height (p>0.05), cross-sectional area, number of profiles per unit area and numerical density,
PAS-positive materials and Ki67 cells of seminiferous tubules of the rats treated with cisplatin alone. Interestingly, all these parameters
were attenuated in the groups that were post-treated with the extract. Conclusion: Based on these evidenced it was concluded that
aqueous zest extract of Citrus paradisi have curative roles in the abatement of cisplatin-induced testicular toxicity in Wistar rats.]]>Howard, C.V. and M. Reed,20052nd Edn.,pp: 103-104pp: 103-104Yama, O.E., A.C. Ifeanyi, S.A. Oyebadejo, C.C. Noronha, S.L. Chai and A.O. Okanlawon,2011Momordica charantia.]]>213901394Xu, G.H., J.C. Chen, D.H. Liu, Y.H. Zhang, P. Jiang and X.Q. Ye,200873C11C18Mohamed, N.A.E., A.A. Tohamy, B. Elgamal and A.E.A. Moneim,201446468Green, C.O., A.O. Wheatley, D.A. Mcgrowder, L.L. Dilworth and H.N. Asemota,201351306309Ravindra, P., D.A. Bhiwgade, S. Kulkarni, P.V. Rataboli and C.Y. Dhume,20104108111Mashhadi, M.A., Z. Heidari and Z. Zakeri,201372327Townsend, D.M., M. Deng, L. Zhang, M.G. Lapus and M.H. Hanigan,200314110Yao, X., K. Ichpisal, N, Kurtzman and K. Nugent,2007334115124Malarvizhi, D. and P.P. Mathur,199634995998Cherry, S.M., P.A. Hunt and T.J. Hassold,2004564115128Che, C.M. and F.M. Siu,201014255261Cvitkovic, E.,19982513Liogier, H.A.,1994Saalu, L.C., V.A. Togun, A.O. Oyewopo and Y. Raji,2006628892894CCAC.,1985Vol. 23,pp: 45-47pp: 45-47WMA and APS,2002283R281R283Sonmez, M., G. Turk and A. Yuce,20056320632072Yokoi, K. and Z.K. Mayi,20042907885Atessahin, A., I. Karahan, G. Turk, S. Gur, S. Yilmaz and A.O. Ceribasi,2006214247Sheehan, D.C. and B.B. Hrapchak,19872nd Edn,pp: 39-40pp: 39-40Qin, D. and M.A. Lung,200244953Gundersen, H.J.G. and E.B. Jensen,1987147229263Cohen, S.M. and S.J. Lippard,20016793130Cepeda, V., M.A. Fuertes, J. Castilla, C. Alonso, C. Quevedo and J.M. Perez,20077318Setchell, B.P. and D.E. Brooks,19881988pp: 753-836pp: 753-836Creasy, D.M.,200368408415Malarvizhi, D. and P.P. Mathur,199533281283Ganaie, M.A.,201551521Vawda, A.I.,1994325357Xu, B., S.E. Chia, M. Tsakok and C.N. Ong,19937613618Zhang, X., N. Yamamoto, S. Soramoto and I. Takenaka,2001464349Sasaki, K., T. Murakami, M. Kawasaki and M. Takahashi,1987133579584Scholzen, T. and J. Gerdes,2000182311322Ferrara, D., N. Hallmark, H. Scott, R. Brown, C. McKinnell, I.K. Mahood and R.M. Sharpe,2006in utero exposure of rats to di(n-butyl) phthalate on testicular germ cell development and proliferation.]]>14753525362Gomez-Lazaro, M., F.J. Fernandez-Gomez and J. Jordan,200460287307Boekelheide, K., H.A. Schoenfeld, S.J. Hall, C.C. Weng and G. Shetty et al.,2005Macaca arctoides) from radiation-induced spermatogenic failure.]]>26222234Nakai, M., R.A. Hess, J. Netsu and T. Nasu,199516410416Narayana, K., U.J.A. D'Souza, P. Narayan and G. Kumar,2005646571Maines, M.D., P.M. Sluss and M. Iscan,1989cis-Platinum-mediated decrease in serum testosterone is associated with depression of luteinizing hormone receptors and cytochrome P-450scc in rat testis.]]>12623982406Cameron, D.F., K.E. Muffly and S.J. Nazian,1993202457464Davies, K.J.A.,199561131Kim, Y.K., J.S. Jung, S.H. Lee and Y.W. Kim,19972+ in cisplatin-induced cell injury in rabbit renal cortical slices.]]>146261269Cao, L., S. Leers-Sucheta and S. Azhar,2004886167Kirsi, T. and J. Timo,200124634644Kalender, Y., M. Yel and S. Kalender,20052093945Vernet, P., R.J. Aitken and J.R. Drevet,20042163139Garside, D.A. and P.W. Harvey,19921992pp: 285-312pp: 285-312Lafuente, A. and A.I. Esquifino,1999110209218Silici, S., O. Ekmekcioglu, G. Eraslan and A. Demirtas,200974545551Cai, L., B.F. Hales and B. Robaire,19975614901497Huddart, R.A., J. Titley, D. Robertson, G.T. Williams, A. Horwich and C.S. Cooper,199531739746Chresta, C.M., J.R. Masters and J.A. Hickman,19965618341841Meistrich, M.L., M. Finch, M.F. da Cunha, U. Hacker and W.W. Au,198242122131Laskey, J.W., G.H. Rehnberg, S.C. Laws and J.F. Hein,198473250255Bailey, T.L., R.S. Hudson, T.A. Powe, M.G. Riddell, D.F. Wolfe and R.L. Carson,1998in vivo.]]>49581594Yang, H.S., D.K. Han, J.R. Kim and J.C. Sim,200621445451Azu, O.O., I.O.D. Francis, A.O. Abraham, C.N. Crescie, O.E. Stephen and O.O. Abayomi,201038488Lirdi, L.C., T. Stumpp, E. Sasso‐Cerri and S.M. Miraglia,2008291797808Peng, S.J., R.K. Lu and L.H. Yu,1997Rhizoma curculiginis, Radix morindae officinalis on human spermatozoan's motility and membrane function in vitro].]]>17145147, (In Chinese)Amin, A. and A.A. Hamza,20068607612Amin, A., D. Mahmoud-Ghoneim, M.I. Syam and S. Daoud,20122012Ilbey, Y.O., E. Ozbek, M. Cekmen, A. Simsek, A. Otunctemur and A. Somay,20092417171725Yüce, A., A. Ateşşahin, A.O. Çeribaşı and M. Aksakal,2007101345349Atasayar, S., H. Gurer-Orhan, H. Orhan, B. Gurel, G. Girgin and H. Ozgunes,2009612332