International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2010.141.153TawfiekH.M. El-RehimD.M. Abd ElsherbnyY.M. TawfikE.R. 3201063The aim of the study was to evaluate the expression of Macrophage
Inhibitory Cytokine-1 (MIC-1) in benign and malignant prostate tissues and to
associate its expression with clinicopathological parameters of prostate cancer.
Immunohistochemical analysis of MIC-1 expression was performed on 21 benign
prostatic hyperplasia (BPH), 21 prostatic intraepithelial neoplasia (PIN) and
31 prostate cancer (PCa) tissues. Expression was semiquantitatively scored by
assessing both the percentage and intensity of positive staining cells. Expression
levels were compared in different lesions and relations between MIC-1 expression
with Gleason's grade, stage, serum MIC-1 and prostate specific antigen (PSA),
measured by enzyme-linked immunosorbent assay, were investigated. Significantly
higher immunostaining scores in LGPIN, HGPIN and Pca compared to BPH (p = 0.004,
0.001, <0.001, respectively) were detected. Much higher MIC-1 overexpression
levels in PCa (92%), HGPIN (76.9%), LGPIN (75%) were observed than BPH (38.1%).
High tissue MIC-1 expression scores were significantly associated with high
Gleason grades and advanced stages. Serum MIC-1 was significantly higher in
PCa patients, when compared to BPH patients and control (p<0.001). A highly
significant correlation was found between tissue and serum MIC-1 in PCa cases
(r = 0.713, p<0.001). These data emphasize the differential expression of
MIC-1 during prostate cancer development and progression. Its upregulation from
benign to malignant prostate lesions and in aggressive and advanced prostate
cancer suggests that MIC-1 should be evaluated as a potential diagnostic and
prognostic marker in prostate cancer.]]>Albertoni, M., P.H. Shaw, M. Nozaki, S. Godard and M. Tenan et al.,20022142124219Ali, S.M.,2005in situ hyberdization.]]>159Ames, B.N., L.S. Gold and W.C. Willet,19959252585265Ashida, S., H. Nakagawa, T. Katagiri, M. Furihata and M. Iiizumi et al.,20046459635972Baek, K.E., S.R. Yoon, J.T. Kim, K.S. Kim, and S.H. Kang et al.,2009401128133Bauskin, A.R., D.A. Brown, T. Kuffner, H. Johnen and X.W. Luo et al.,20066649834986Bauskin, A.R., D.A. Brown, S. Junankar, K.K. Rasiah and S. Eggleton et al.,20056523302336Bauskin, A.R., H.P. Zhang, W.D. Fairlie, X.Y. He and P.K. Russell et al.,20001922122220Bootcov, J.W.,200666605612Bootcov, M.R., A.R. Bauskin, S.M. Valenzuela, A.G. Moore and M. Bansal et al.,1997941151411519Bostwick, D.G.,1989341622Bottner, M., C. Suter-Crazzolara, A. Schober and K. Unsicker,1999297103110Boyle, G.M., J. Pedley, A.C. Martyn, K.J. Banducci and G.M. Strutton et al.,2009129383391Brown, D.A., C. Stephan, R.L. Ward, M. Law and M. Hunter et al.,2006128996Brown, D.A., R.L. Ward, P. Buckhaults, T. Liu and K.E. Romans et al.,2003926422650Buckhaults, P., C. Rago, B. St Croix, K.E. Romans and S. Saha et al.,20016169967001Buhtoiarov, I.N. P.M. Sondel, J.C. Eickhoff and A.L. Rakhmilevich,2007120412423Chen, S.J., D. Karan, S.L. Johansson, F.F. Lin and J. Zeckser et al.,200767557571Cheung, P.K., B. Woolcock, H. Adomat, M. Sutcliffe and T.C. Bainbridge et al.,20046459295933De Wit, N.J.W., J. Rijntjes, J.H.S. Diepstra, T.H. van Kuppevelt and U.H. Weidle et al.,20059222492261Dumont, N. and C.L. Arteaga,20033531536Eling, T.E., S.J. Baek, M. Shim and C.H. Lee,200639649655Epstein, J.I., F. Algaba, J.R. Allsbrook, S. Bastacky and L. Boccon-Gibod et al.,20042004pp: 359pp: 359Hernes, E., S.D. Fossa, A. Brener, B. Otnes and J.M. Nesland,200490449454Hromas, R., M. Hufford, J. Sutton, D. Xu, Y. Li and L. Lu,199713544044Igawa, T., F.F. Lin, M.S. Lee, D. Karan, S.K. Batra and M.F. Lin,200250222235Jemal, A., R. Siegel, E. Ward, T. Murraya, J. Xu and M.J. Thun, 2007574366Karan, D., J. Holzbeierlein and J.B. Thrasher,20096925Karan, D., S.J. Chen, S.L. Johansson, A.P. Singh, V.M. Paralkar, M.F. Lin and S.K. Batra,2003305598604Karan, D., D.L. Kelly, A. Rizzino, M.F. Lin and S.K. Batra,200223967975Kempf, T., M. Eden, J. Strelau, M. Naguib and C. Willenbockel et al.,200698351360Kim, K.K., J.J. Lee, Y. Yang, K.H. You and J.H. Lee,200829704712Kim, I.Y., D.H. Lee, D.K. Lee, B.C. Kim and H.T. Kim et al.,2003960466051Lawton, L.N., M.F. Bonaldo, P.C. Jelenc, L. Qiu and S.A. Baumes et al.,19972031726Lee, M.S., T. Igawa, T.C. Yuan, X.Q. Zhang, F.F. Lin and M.F. Lin,200322781796Li, P.X., J. Wong, A. Ayed, D. Ngo and A.M. Brade et al.,20002752012720135Liu, T., A.R. Bauskin, J. Zaunders, D.A. Brown, S. Pankhurst, P.J. Russell and S.N. Breit,20036350345040Nakamura, T., A. Scorilas, C. Stephan, G.M. Yousef, G. Kristiansen, K. Jung and E.P. Diamandis,20038811011104Nowroozi, M.R., S. Zeighami, M. Ayati, H. Jamshidian and A.R. Ranjbaran et al.,200962730Paralkar, V.M., A.L. Vail, W.A. Grasser, T.A. Brown and H. Xu et al.,19982731376013767Patrikainen, L., K. Porvari, R. Kurkela, P. Hirvikoski, Y. Soini and P. Vihko,200737126133Polascik, T.J. J.E. Oesterling and A.W. Partin,1999162293306Rasiah, K.K., J.G. Kench, M. Gardiner-Garden, A.V. Biankin and D Golovsky et al.,200615711716Sakr, W.A., R. Montironi, J.I. Epstein, M.A. Rubin and A.M. De Marzo et al.,20042004pp: 360pp: 360Schiemann, W.P., D. Rotzer, W.M. Pfeifer, E. Levi, K.R. Rai, P. Knaus and M.E. Kadin,2004285764Selander, K.S., D.A Brown, G.B Sequeiros, M. Hunter and R. Desmond et al.,200716532537Stamatiou, K., V. Papadimitriou, E. Michail, D. Delakas, E. Michalodimitrakis and F. Sofras,20073162166Stout, R.D. and J. Suttles,200476509513Tan, M., Y. Wang, K. Guan and Y. Sun,200097109114Thomas, R., L.D. True, P.H. Lange and R.L. Vessella,2001934752Vollmer, J.,200625125134Welsh, J.B., L.M. Sapinoso, S.G. Kern, D.A. Brown and T. Liu et al.,200310034103415Welsh, J.B., L.M. Sapinoso, A.I. Su, S.G. Kern and J. Wang-Rodriguez et al.,20016159745978Wollmann, W., M.L. Goodman, P. Bhat-Nakshatri, H. Kishimoto and R.J. Goulet et al.,200526900907Yang, H., Z. Filipovic, D. Brown, S.N. Breit and L.T. Vassilev,2003210231029Zhang, Q., J.N. Rubenstein, T.L. Jang, M. Pins and B. Javonovic et al.,20051923902399McDonald, J.H.,20092nd Edn.,