International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2009.44.52(Citrus paradisi Macfad) as an Effective Attenuator of Doxorubicin-Induced Oxidative Stress in the Rat Heart]]>SaaluL.C. AjayiG.O. AdeneyeA.A. ImosemiI.O. OsinubiA.A. 2200952In the present study, we examined the ameliorating effect
of the 100% ethanol extract of Citrus paradisi (grapefruit) seed
(GSE) on survival of doxorubicin treated rats and on DOX- induced cardiomyopathy.
Whereas only 20% of the rats treated with DOX (20 mg kg-1 body
weight intraperitoneally) survived at the end of 14 days, almost all the
DOX-treated rats survived when GSE (20 mg kg-1 body weight)
was administered by gastric gavage. In the second experiment, GSE (20
mg kg-1 body weight) was administered daily by gavage for 14
consecutive days before a cumulative single dose of DOX (20 mg kg-1
body weight, intraperitoneally) was given. DOX induced marked biochemical
alterations characteristic of cardiac toxicity. There was enhanced lipid
peroxidation measured as malondialdehyde (MDA). The anthracycline antibiotic
drug reduced the cardiac enzymatic activities of superoxide dismutase
(SOD), glutathione S transferase (GST) and catalase (CAT). Besides, it
reduced significantly the reduced glutathione (GSH) level; prior administration
of grapefruit seed extract ahead of doxorubicin challenge ameliorated
all these biochemical markers. Taken together, one could conclude that
grapefruit seed extract has a protective role in the abatement of doxorubicin-induced
cardiac toxicity that resides, at least in part, on its anti-radical effects.]]>Abd El-Aziz, M.A., A.I. Othman, M. Amer and M. Elmissiri,200121469473Adeneye, A.A.,2008Citrus paradisi Macfad (grape fruit) in Wistar rats.]]>192326Armstrong, L.L. and R.J. Lipsy,1993Arola, O.J., A. Saraste, K. Pulkki, M. Kallajoki, M. Parvinen and L.M. Voipio-Pulkki,20006017891792Buyukokuroglu, M.E., S. Taysi, M. Bukavci and E. Baka,200423251256Billingham, M.E., J.W. Mason, M.R. Bristow and J.R. Daniels,197862865872Bristow, M.R., P.D. Thompson, R.P. Martin, J.W. Mason, M.E. Billingham and D.C. Harrison,197865823832Chularojmontri, L., S.K. Wattanapitayakul, A. Herunsalee, S. Charuchongkolwongse, N. Niumsakul and S. Srichairat,2005Phyllanthus urinaria L. on doxorubicin-induced cardiotoxicity.]]>2811651171Clairborne, A.,19851985pp: 283-284pp: 283-284Conklin, K.A.,2005411101130Cook, N.C. and S. Samman,199676676Davies, K.J. and J.H. Doroshow,198626130603067Deepa, P.R. and P. Varalakshmi,2003146201210Diplock, A.T., J.L. Charuleux, G. Crozier-Willi, F.J. Kok and C. Rice-Evans et al.,199880S77S112Doroshow, J.H., G.Y. Locker and C.E. Myers,198065128135Ellman, G.L.,1959827077Habig, W.H., M.J. Pabst and W.B. Jakoby,197424971307139Hasinoff, B.B.,19982539Herman, E.H., J. Zhang and V.J. Ferrans,19943593100Ho, C.T.,1994Hrdina, R., V. Gersl, I. Klimtova, T. Simunek, J. Mach and M. Adamcova,2000437582Kang, Y.J., Y. Chen and P.N. Epstein,19962711261012616Kang, Y.J., Y. Chen, A .Yu, M. Voss-McCowan and P.N. Epstein,199710015011506Koning, J., P. Palmer, C.R. Franks, D.E. Mulder, J.L. Speyer, M.D. Green and K. Hellmann,199118119Lacy, C., L.L. Armstrong and R.J. Lipsy,1993Lee, M.K., S.H. Bok, T.S. Jeong, S.S. Moon, S.E. Lee, Y.B. Park and M.S. Choi,20021022392244Marklund, S.L.,19851985Nazeyrollas, P., A. Prevost, N. Baccard, L. Manot, P. Devillier and H. Millart,199943227232Olson, R.D. and P.S. Mushlin,1990430763086Quiles, J.L., J.R. Huertas, M. Battino, J. Mataix and C.M. Ramirez-Tortosa,20021807995Sachs, A.,1997pp: 775-795pp: 775-795Samelis, G.F., G.P. Stathopoulos, D. Kotsarelis, I. Dontas, C. Frangia and P.E. Karayannacos,19981833053309Sehested, M., J.B. Jensen, B.S. Sorensen, B. Holm, E. Friche and E.J. Demant,199346389393Siveski-Iliskovic, N., N. Kaul and P.K. Singal,19948928292835Siveski-Iliskovic, N., M. Hill, D.A. Chow and P.K. Singal,1995911015Tokarska-Schlattner, M., M. Zaugg, C. Zuppinger, T. Wallimann and U. Schlattner,200641389405Uchiyama, M. and M. Mihara,197986271278Wallace, K.B.,200393105115Xu, M.F., P.L. Tang, Z.M. Qian and M. Ashraf,200168889901Ytrehus, K.T. and A.C. Hegstad,1991324843845Zhou, S., A. Starkov, M.K. Froberg, R.L. Leino and K.B. Wallace,200161771777