International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2009.130.143Ocimum basilicum L. and Ocimum tenuiflorum
L.)]]>GajulaD. VergheseM. BoatengJ. WalkerL.T. ShackelfordL. MentreddyS.R. CedricS. 4200954Basil (Ocimum basilicum L. and Ocimum tenuiflorum L.) contains important phytochemicals that have been reported to afford protection against several chronic diseases due to their anti-inflammatory and antioxidant activities. The purpose of this study was to determine the effects of three accessions of Ocimum tenuiflorum (Holy Basil) Denmark (HBD), Cuba (HBC), India (HBI)) and one accession of Ocimum basilicum (Culinary Basil) (CB) at 1 and 2% levels on azoxymethane (AOM) induced Aberrant Crypt Foci (ACF) in Fisher 344 male rats and to determine the effect of oven drying on total phenolics, flavonoids and anthocyanins of Basil and antioxidative activity. Fifty four rats were divided into 9 groups (n = 6) after a 1 week period of acclimatization. Group 1 was fed a control (C) diet (AIN-93 G) and remaining groups were fed C+1 or 2% CB, HBD, HBC and HBI. All rats received s/c injections of AOM in saline at 16 mg kg-1 b.wt. at 7 and 8 week of age. Rats were killed by CO2 asphyxiation at 17 week of age. The ACF in rats fed C (158.1) was higher than in rats fed C+1% CB, HBD, HBC, HBI (77, 86, 76, 73) and C+2% CB, HBD, HBC, HBI (65, 78, 61, 67). The GST and CAT activities (μmol mg-1) in rats fed C+1 and 2% CB, HBD, HBC and HBI were significantly (p<0.05) higher compared to C. Results showed that feeding culinary and Holy Basil leaves reduced the number of AOM-induced ACF and therefore may have implications in the food industry as a potential chemopreventive agent.]]>Aebi, H.,1984in vitro.]]>1984pp: 121-126pp: 121-126Aruna, K. and V.M. Sivaramakrishnan,19902810081011Beric, T., B. Nikolic, J. Stanojevic, B. Vukovic-Gacic and J. Knezevic-vukcevic,2008Ocimum basilicum L.) against oxidative DNA damage and mutagenesis.]]>46724732Block, K.I. and C. Gyllenhaal,200218389Bianchi, L.K. and C.A. Burke,200875441448Bird, R.P.,198737147151Coates, E.M, G. Popa, C.I.R. Gill, M.J. McCann, G.J. McDougall, D. Stewart and I. Rowland,2007644Dasgupta, T., A.R. Rao and P.K. Yadava,2004Ocimum basilicum) on drug metabolizing and antioxidant enzymes, and on carcinogen-induced skin and forestomach papillomagenesis.]]>11139151Dewanto, V., X. Wu, K.K. Adom and R.H. Liu,20025030103014Gulcin, I., M. Elmastas and H.Y. Aboul-Enein,2007Ocimum basilicum L. Family Lamiaceae) assayed by different methodologies.]]>21354361Habig, W.H., M.J. Pabst and W.B. Jakoby,197424971307139Hakkim, F.L., C.G. Shankar and S. Girija,2007Ocimum sanctum L.) leaves, stems and inflorescence and their in vitro callus cultures.]]>5591099117Issa, A.Y., S.R. Volate and M.J. Wargovich,200619405419Chamila, J., G. Naohiro, A. Tomako and W. Shun,2003Ocimum basilicum L.).]]>5144424449Johnson, J.J. and H. Mukhtar,2007255170181Kim, D.O., O.K. Chun, Y.J. Kim, H.Y. Moon and C.Y. Lee,20035165096515Kim, D.S., H.R. Kim, E.R. Woo, S.T. Hong, H.J. Chae and S.W. Chae,20057010661078Loughrin, J.H. and M.J. Kasperbauer,2001Ocimum basilicum L.) leaves.]]>4913311335Mazza, G. and E. Miniati,1993Ist Edn.,Phippen, W.B. and J.E. Simon,1998Ocimum basilicum L.).]]>4617341738Prakash, J. and S.K. Gupta,2000722934Reeves, P.G., F.H. Nielsen and G.C. Fahey Jr.,199312319391951Scalbert, A. and G. Williamson,20001302073S2085SShirtliff, N. and R.P. Bird,19961720932096Simon, J.E., M.R. Morales, W.B. Phippen, R.F. Vieira and Z. Hao,19991999pp: 499-505pp: 499-505Singleton, V.L., R. Orthofer and R.M. Lamuela-Raventos,19991999pp: 152-178pp: 152-178Sohn, O.S., F.S. Emerich, S.P. Requeijo, J.H. Weisburger and F.J. Gonzalez,20016184358440Suppakul, P., J. Miltz, K. Sonneveld and S.W. Bigger,20035131973207Devi, P.U.,2001Ocimum sanctum (Tulasi).]]>39185190Verghese, M., D.R. Rao, C.B. Chawan and L. Shackelford,200213228042808Wolfe, K., X. Wu and R.H. Liu,200351609614Naoyuki, Y., M. Toshinari, O. Masahiko and E. Hiroyasu,199485692698SAS.,2004Version 9,Ashokkumar, P. and G. Sudhandiran,200862590597