International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2008.52.60SunkaraR. VergheseM. PanalaV. FieldR. BoatengJ. ShackelfordL.A. WalkerL.T. 2200842In this study, the chemopreventive potential of Cranberry
was analyzed in reducing the Aberrant Crypt Foci (ACF) induced by Azoxymethane
(AOM) in Fisher 344 male rats. After 1 week period of acclimatization,
rats were divided into five different groups. Cranberry meal was mixed
in an AIN 93G based diet at 5 and 10% and juice was provided at 2.5 and
5%. Daily feed intake and weekly body weights were recorded. At 17 week
of age, rats were killed and samples were collected. Number of ACF and
number of cypts/foci were enumerated in the colon. There were no significant
differences in feed intake, weight gain, cecal weight and cecal pH among
all groups. Total ACF incidence (119) was significantly (p<0.05) higher
in control group than in treatment groups. Reduction in total ACF induction
was higher in rats fed 10% Cranberry (65.75%) compared to control. A two
to six fold increase in selected hepatic enzymes activities (units/mg
enzyme) were seen in rats fed 5 and 10% treatment diets compared to control.
Results of this study showed that administration of Cranberry meal and
juice resulted in significant (p<0.05) reductions in the incidence
of ACF in azoxymethane induced preneoplastic lesions.]]>Aebi, H.,1984in vitro.]]>1984pp: 121-126pp: 121-126American Cancer Society,20051st Edn.,Atalay, M., G. Gordillo, S. Roy, B. Rovin, D. Bagchi, M. Bagchi and C.K. Sen,2003544252257Bagchi, D., A. Garg, R.L. Krohn, M. Bagchi, M.X. Tran and S.J. Stohs,1997in vitro.]]>95179189Bagchi, D., C.K. Sen, M. Bagchi and M. Atalay,20046999102Bird, R.P.,198737147151Block, G., B. Patterson and A. Subar,199218129Bomser, J., D.L. Madhavi, K. Singletary and M.A. Smith,1996In vitro anticancer activity of fruit extracts from Vaccinium species.]]>62212216Castenmiller, J.J.M., S.T. Lauridsen, L.O. Dragsted, K. Van het Hof, J.P.H. Linssen and C.E. West,199912921622169Clifford, M.N.,20028010631072Duthie, S.J., A.M. Jenkinson, A. Crozier, W. Mullen, L. Pirie, J. Kyle, L.S. Yap, P. Christen and G.G. Duthie,200645113122Ferguson, P.J., E. Kurowska, D.J. Freeman, A.F. Chambers and D.J. Koropatnick,200413415291535Fiala, E.S.,19774024362445Fridovich, I.,198925477617764Habig, W.H., M.J. Pabst and W.B. Jakoby,197424971307139Hou, D.X., T. Ose, S. Lin, K. Harazoro, I. Imamura, M. Kubo, T. Uto, N. Terahara, M. Yoshimoto and M. Fujii,200323705712Jemal, A., T. Murry, E. Ward, A. Samuels, R. Tiwari, A. Ghafoor, E.J. Feuer and M.J. Thun,2007551030Kandil, F.E., M.A.L. Smith, R.B. Rogers, M.F. Pepin, L.L. Song, J.M. Pezzuto and D.S. Seigler,20025010631069Kassie, F., S. Rabot, M. Uhl, W. Huber and H.M. Qin et al.,2002Lepidium sativum) and its constituents towards 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ)-induced genotoxic effects and colonic preneoplastic lesions.]]>2311551161Kondo, M., T.L. Lamoureaux, C.C. Neto, R.A.R. Hurta and S. Curtis et al.,20041343521S3547SKoop, D.R., B. Klopfenstein, Y. Iimuro and R.G. Thurman,199751944950Lala, G., M. Malik, C. Zhao, J. He, Y. Kwon, M.M. Giusti and B.A. Magnuson,2006548493Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall,1951193265275Moghadasian, M.H., H.J. Freeman and D.V. Godin,199617983987Murphy, B.T., S.L. MacKinnon, X. Yan, G.B. Hammond, A.J. Vaisberg and C.C. Neto,2003in vitro antitumor activity from whole cranberry fruit (Vaccinium macrocarpon).]]>5135413545Neto, C.C.,2007in vitro anticancer studies.]]>137186S193SNielsen, S.E., J.F. Young, B. Daneshvar, S.T. Lauridsen, P. Knuthsen, B. Sandstrom and L.O. Dragsted,1999Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects.]]>81477485Ranelletti, F.O., N. Maggiano and F.G. Serra,200085438445Reed, J.,200242301316Roy, S., S. Khanna, H.M. Alessio, J. Vider, D. Bagchi, M. Bagchi and C.K. Sen,20023610231031Santillo, V.M. and F.C. Lowe,2007434754Seeram, N.P., L.S. Adams, M.L. Hardy and D. Heber,20045225122517Sengottuvelan, M., P. Viswanathan and N. Nalini,20062710381046Steinmetz, K.A. and J.D. Potter,19969610271039Sun, J. and R.H. Liu,2006241124134Vinson, J.A., X. Su, L. Zubik and P. Bose,20014953155321Volate, S.R., D.M. Davenport, S.J. Muga and M.J. Wargovich,20052614501456Yan, X., B.T. Murphy, G.B. Hammond, J.A. Vinson and C.C. Neto,2002Vaccinium macrocarpon).]]>5058445849Young, J.F., S.E. Nielsen, J. Haraldsdottir, B. Daneshvar and S.T. Lauridsen et al.,1999698794Zhang, L., J. Ma, K. Pan, V.L. Go, J. Chen and W.C. You,2005Helicobacter pylori infection: A double-blind, randomized placebo-controlled trial.]]>10139145