International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2008.20.27Pereskia bleo (Cactaceae) Against Selected Human Cell Lines]]>MalekSri Nurestri Abd WahabNorhanom Abdul YaacobHashim ShinSim Kae LaiHong Sok SermLee Guan RahmanSyarifah N.S.A. 1200841Pereskia bleo (Cactaceae) was investigated for
its cytotoxic effect against selected human cell lines, namely the Human
Nasopharyngeal Epidermoid Carcinoma Cell Line (KB), Human Cervical Carcinoma
Cell Line (CasKi), Human Colon Carcinoma Cell Line (HCT 116), Hormone-Dependent
Breast Carcinoma Cell Line (MCF7) and non-cancer Human Fibroblast Cell
Line (MRC-5) by using an in vitro neutral red cytotoxicity assay.
All the crude methanolic and its fractionated extracts (hexane, ethyl
acetate and water) exert no damage to the MRC-5 normal cells. The crude
methanol extract and the ethyl acetate fraction of Pereskia bleo
possessed notably high cytotoxic effect against KB cells with IC50
values of 6.5 and 4.5 μg mL-1, respectively. Four
compounds isolated from the ethyl acetate fraction of Pereskia bleo
were identified as phytol, β-sitosterol, 2,4-di-tert-butylphenol
and vitamin E. All four compounds have not been reported for this plant.]]>Awad, A.B., A.C. Downie and C.S. Fink,20005541546Bermudez, Y., S. Ahmadi, N.E. Lowell and P.A. Kruk, 200731119128Block, S., C. Baccelli, B. Tinant, L.C. Meervelt and R. Rozenberg et al.,2004Croton zambesicus.]]>6511651171Borenfreund, E. and J.A. Puerner,1985979Chaturvedula, V.S.P., J.K. Schilling,J.S. Miller, R. Andriantsiferana, V.E. Rasamison and D.G.I. Kingston,2002Brachylaena ramiflora from the Madagascar rainforest.]]>6512221224Doetsch, P.W., J.M. Cassady and J.L. McLaughlin,1980Pereskia, Pereskiopsis and Islaya by use of fluorescamine conjugates.]]>1897985Drisko, J.A., J. Chapman and V.J. Hunter, 200388434439Goh, K.L., 20001st Edn.,Hibasami, H.K., Masaki, O. Shinnji, K.H. Imai, K. Ohnishi, K. Ina and K.K. Takashi, 200210555559Jackson, S.J., P.J. Houghton, S. Retsas and A. Photiou,2000In vitro cytotoxicity of norviburtinal and isopinnatal from Kigelia pinnata against cancer cell lines.]]>66758761Kamitori, Y., M. Hojo, R. Masuda, T. Izumi and S. Tsukamoto,19844941614165Komiya, T., M. Kyohkon, S. Ohwaki, J. Eto and H. Katsuzaki et al.,19994377457Lamson, D.W. and M.S. Brignall, 19994304329Lee, K., S.H. Rhee and K.Y. Park,19992811071112Shan, M.D., T.Y. An, L.H. Hu and Z.L. Chen,2004Hypericum perforatum.]]>181519Moghadasian, M.H., 2000In vivo and in vitro observations.]]>67605615Nes, W.D., R.A. Norton and M. Benson,199213C]mevalonates.]]>31805811Pereira, A.S., D.S. Siqueira, V.O. Elias, B.R.T. Simoneit, J.A. Cabral and F.R.A. Neto, 200261711719Phutdhawong, W., D. Arworn, K. John, P. Stephen, G. Picha, P. Ngamkham, J. Buddhasukh and Duang, 2004Streblus asper.]]>19445447Schreck, R., K. Albermann and A. Baeuerle,199217221237Swanson, S.M. and J.M. Pezzuto, 19901990pp: 273-297pp: 273-297Tanaka, T., H. Makita, M. Ohnishi, H. Mori and K. Satoh et al.,199757246252Tan, M.L., S.F. Sulaiman, N. Najimuddin, M.R. Samian and T.S. Tengku Muhammad,2005Pereskia bleo (Kunth) DC. (Cactaceae) induces apoptosis in breast carcinoma, T47-D cell line.]]>96287294Yoshioka, K., T. Deng, M. Cavigelli and M. Karin,19959249724976Yu, R., T.H. Tan and A.N. Kong,19972722896228970