International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2008.154.159Zingiber zerumbet]]>WahabS.I.A. AbdulA.B. Yee1H.C. AlzubairiA.S. ElhassanM.M. SyamM.M. 4200844 The aim of this study is to evaluate some derivatives
of Zerumbone for their anti-tumor effects towards human cervical cancer
cell lines (HeLa). The MTT tetrazolium salt colorimetric assay was utilized
to evaluate the cytotoxic effects of ZER, cisplatin and the derivatives
were n-Butylbenzene (compound 5), 1,1`-(4-Chlorobutylidene) bis(4-fluorobenzene)
(compound 6), alpha, alpha-Diphenyl-gamma-butyrolactone (compound 7) and
(1,4`-Bipiperidine)-4`-carboxaminde (compound 8). The results of this
study showed that derivatives of ZER have shown lesser anti-tumor effects
towards HeLa cancer cells compared to the principal compound (ZER).]]>Bogevik, A.S., A. Oxley and R.E. Olsen,200843655662Crowell, P.L.,1999129775S778SDamodaran, N.P. and S. Dev,1968Zingiber zerumbet smith.]]>2441134122Ertl, P., S. Roggo and A. Schuffenhauer,2008486874Geran, R., N. Greenberg, M. MacDonaald, A. Schumacher and B. Abbott,19723163Gerlier, D. and N. Thomasset,1986945763Jang, D.S., H.Y. Min, M.S. Kim, A.R. Han and T. Windono et al.,200553829831Kirana, C., G.H. McIntosh, I.R. Record and G.P. Jones,200345218225Kitayama, T., T. Yokoi, Y. Kawai, R.K. Hill and M. Morita et al.,20035948574866Koehn, F.E.,200865:175177210Matthes, H.W.D., B. Luu and G. Ourisson,1980Zingiber zerumbet, Curcuma zedoaria and C. domestica.]]>1926432650Mosmann, T.,1983655563Murakami, A., R. Hayashi, T. Tanaka, K.H. Kwon, H. Ohigashi and R. Safitri,20036612531261Murakami, A., D. Takahashi, T. Kinoshita, K. Koshimizu and H.W. Kim et al.,200223795802Nakamura, Y., Y. Chiho, A. Murakami, H. Ohigashi, T. Osawa and K. Uchida,2004572245250Nharet-Somchit, N.M. and M.H. Nur-Shukriah,2003Zingiber zerumbet. ]]>35181182Nielsen, J.,20026297305Ortholand, J.Y. and A. Ganesan,20048271280Perry, L.M.,19801st Edn.,Pages: 632Pages: 632Rabi, T. and S. Gupta,20081334573469Saif, M.W.,20082008pp: 403407Yu, F., S. Okamto, K. Nakasone, K. Adachi and S. Matsuda et al.,2008Zingiber zerumbet smith).]]>22712911299