International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2008.146.153GuytonM. VergheseM. T. WalkerL. B. ChawanC. ShackelfordL. JonesJ. KhatiwadaJ. 4200844The aim of this study was to explicate the effect of
feeding peanuts at 3 levels (10, 15 and 20 g 100-1 g of feed)
on azoxymethane (AOM)-induced Aberrant Crypt Foci (ACF) in Fisher 344
male rats. Four groups of rats were fed AIN93-G control diet (n = 8) and
3 experimental diets containing 10, 15 and 20% peanuts (n = 8) for 13
weeks. All rats received 16 mg kg-1 body weight of AOM at 7
and 8 week of age. The rats continued to receive the assigned diets until
euthanized by CO2 at 17 weeks of age. The percent reductions
in ACF in the groups consuming diets containing 10, 15 and 20% peanuts
were 31.9, 48.7 and 61%, respectively. GST activity (μmol mg-1)
in the rats fed control diet was significantly (p<0.05) lower compared
to the rats fed peanuts. Present results indicate that feeding peanuts
significantly reduced AOM-induced ACF in Fisher 344 male rats. The phytochemicals
present in peanuts may have antitumor properties and could possibly reduce
colon cancer.]]>Jemal, A., E. Ward, Y. Hao and Y.M. Thun,200529412551259Aziz, M.H., R. Kumar and N. Ahmad,2003In vitro and in vivo studies and the underlying mechanisms (review).]]>231728Bird, R.P.,198737147151Caderni, G., C. De Filippo, C. Luceri, M. Salvadori, A. Giannini and A. Biggeri et al.,20002119651969Cal, C., H. Garban, A. Jazirehi, C. Yeh, Y. Mizatani and B. Bonavida,200327793Doll, R.,1998Epidemiological evidence of the effects of behaviour and the environment on the risk of human cancer.]]>154321Dwivedi, C., L.A. Muller, D.E. Goetz-Parten, K. Kasperson and V.V. Mistry,200312934Eaton, D.L. and T.K. Bammler,199949156164Fontecave, M., M. Lepoivre, E. Elleingand, C. Gerez and O. Guittet,1998421277279Geleijnse, J.M.M., L.J. Launer, A. Hofman, H.A. Pols and J.C. Witterman,199915921702174Hertog, M.G.L., E.J.M. Feskens, D. Kromhout, M.G.L. Hertog, P.C.H. Hollman, M.G.L. Hertog and M.B. Katan,199334210071011Hertog, M.G., D. Kromhout, C. Aravanis, H. Blackburn, R. Buzina and F. Fidonza et al.,1995155381386Jang, M., L. Cai, G.O. Udeani, K.V. Slowing, C.F. Thomas and C.W.W. Beecher et al.,1997275218220Jemal, A., T. Murry, E. Ward, A. Samuels and R. Tiwari et al.,2005551030Keli, S.O., M.G. Hertog, E.K. Feskens and D. Kromhout,1996159637642Lodovici, M., C. Casalini, C. De Filippo, E. Copeland, X. Xu, M. Clifford and P. Dolara,20003810851088Middleton, Jr. E. and C. Kandaswami,19924311671179Potter, J.D., M.L. Slattery, R.M. Bostick and S.M. Gapstur,199315499545Pretlow, T.P., B.J. Barrow, W.S. Ashton, M.A. Riordan, T.G. Pretlow, J.A. Jurcisek and T.A. Stellato,19915115641567Reeves, P.G., K.L. Rossow and J. Lindlauf,199312319231931Reeves, P.G., F.H. Nielsen and G.C. Fahey Jr.,199312319391951Renaud, S. and M. de Lorgeril,199233915231526Rice-Evans, C.A., N.J. Miller, P.G. Bolwell, P.M. Bramley and J.B. Pridham,199522375383Rowland, I.R., C.J. Rumney, J.T.Coutts and L.C. Lievense,199819281285Steele, V.E., G.J. Kelloff, D. Balentine, C.W. Boone, R. Mehta and D. Bagheri et al.,2000in vitro bioassays.]]>216367Stoehlmacher, J., D.J. Park, W. Zhang, S. Groshen, D.D. Tsao-Wei and M.C. Yu et al.,200294936942Verghese, M., D.R. Rao, C.B. Chawan, L.L. Williams and L. Shackelford,200213228092813