International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2008.137.145KhanMuhummadh JamilKaiser 4200844In the present study, we tried to integrate information
from various sources to understand the role of cancer metasignature genes
in initiation and progression of neoplasia. We analyzed these cancer metasignature
genes for their chromosomes distribution, expression profiles in normal
human tissues and the cellular pathways in which they are involved using
the relevant data from the biological databases. It is concluded that
cancer metasignature genes are needed for proper functioning and maintenance
of normal cellular physiology. We report that multiple numbers of these
genes were involved in three cellular processes; cell division cycle,
antigen processing and presentation and proteasome dependent proteolysis.
They are also involved in a myriad of metabolic and genetic processes.
We propose that it is possible that almost all cell types of the human
body contain a dormant genetic network which enables them to overcome
senescence or evade apoptosis. This network when activated due to some
effective trigger may lead to cancer generation and progression.]]>Abbasi, A.A. and K.H. Grzeschik, 20077239239Bucca, G., G. Carruba, A. Saetta, P. Muti, L. Castagnetta and C.P. Smith, 200410282837Bruford, E.A., M.J. Lush, M.W. Wright, T.P. Sneddon, S. Povey and E. Birney, 200836445448De Pitta, C., L. Tombolan, M. Campo Dell'Orto, B. Accordi and G. Te-Kronnie, et al.,200590890898Ferrari, S., 200663781795Forbes, S., J. Clements, E. Dawson, S. Bamford and T. Webb et al.,200694318322Forsburg, S.L., 200836114119Gonzalez-Duarte, R. and R. Albalat, 200595184197Goodsell, D.S., 200523454455Greenman, C., P. Stephens, R. Smith, G.L. Dalgliesh and C. Hunter et al.,2007446153158Halvorsen, O.J., A.M. Oyan, T.H. Bo, S. Olsen and K. Rostad et al.,200526329336Hanai, T., H. Hamada and M. Okamoto, 2006101377384Hernandez, D., A. Janmohamed, P. Chandan, I.R. Phillips and E.A. Shephard,200414117130Hershko, A., 20051211911197Higgins, M.E., M. Claremont, J.E. Major, C. Sander and A.E. Lash,200735D721D726Kaiser, J., 2005309693693Kanehisa, M., M. Araki, S. Goto, M. Hattori and M. Hirakawa et al.,200836480484Kim, T.Y., Y.J. Bang and K.D. Robertson, 200611423Kim, T.M., H.J. Jeong, M.Y. Seo, S.C. Kim and G. Cho et al., 2005117986Lai, C.Q., L.D. Parnell and J.M. Ordovas, 200516153166Lim, E.K. and D.J. Bowles, 20042329152922Malumbres, M., 200712S45S52Rhodes, D.R., J. Yu, K. Shanker, N. Deshpande and R. Varambally et al., 200410193099314Stewart, B.W. and P. Kleihues, 20032003Talbot, S.G., C. Estilo, E. Maghami, I.S. Sarkaria and D.K. Pham et al.,20056530633071Tang, Y., Z. Wang, Y. Huang, D.P. Liu, G. Liu, W. Shen, X. Tang, D. Feng and C.C. Liang,200611123131Taylor, S.S., M.I. Scott and A.J. Holland,200412599616Wheeler, D.L., D.M. Church, A.E. Lash, D.D. Leipe and T.L. Madden et al.,2001291116Wilming, L.G., J.G. Gilbert, K. Howe, S. Trevanion, T. Hubbard and J. L. Harrow,200836D753D760Wolffe, A.P.,1996272371372Zhang, B., S. Kirov and J. Snoddy,200533W741W748