International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2007.103.110Tetrahydronaphthalenthiazol Derivatives as Anticancer Compounds]]>AliMamdouh M. HassanSohair A. 2200732Three newly synthesized tetrahydronaphthalenthiazol derivatives I, II and III were examined to elucidate their antitumor activity against Ehrlichs ascites carcinoma cells (EATCs) bearing mice through monitoring the tumor volume and life span of the mice. All the three compounds showed high antitumor potential in simultaneous treatment than the groups in which treatment was started 10 days post tumor inoculation especially compound III which showed highest activity on reduction tumor volume (from 6.00±0.46 to 2.10±0.18 CC) at 20 μg kg-1 b.w. in comparison to group treated with cisplatin which was used as a standard treatment drug and revealed reduction of tumor volume (from 6.00±0.46 to 0.50±0.04 CC) and also showed the most highest survival rate (34.50±2.70 days) with the increase of life span 67% at the same concentration compared to 74 and 0% in cisplatin and control groups, respectively. It is obviously from the present study that the tetrahydronaphthalenthiazol can possess antitumor activity and ameliorate and prolong the life span of mice bearing EATCs.]]>Ahluwalia, G.S., H.N. Jayaram, J.P. Plowhan, D.A. Cooney and D.G. Johns,19843311951203Al-Thebeity, M.S.,2001140221223Ajith, T.A. and K.K. Janardhanan,2003Phellinus rimosus (Berk) Pilat.]]>84157162Appelbe, R., M. Casey, A. Dunne and E. Pascarella,20034476417644Buc-Calderon, P., M. Preat, J.M. Ruysschaert and M. Roberfroid,198925679685Elslager, E.F., C. Hess, J. Johnson, D. Ortwine, V. Chu and M.W. Leslie,198142127140Ferrante, A., J. Augliera and K. Lewis,1995Escherichia coli: The unexpected role of alkylhydroperoxide reductase.]]>9276177621Fevieg, T., J.L. loyd, J. Zablock and J. Katzenellenbogen,198730156162Fregona, D., L. Roncon and C. Marzano,20032003Ghosh, M.N.,19841984pp: 153-158pp: 153-158Giovagnini, L., L. Ronconi, D. Aldinucci, D. Lorenzon, S. Sitran and D. Fregona,2005in vitro cytotoxicity studies of platinum (II).]]>4815881591Hara, H., T. Fujihashi and T. Salta,199713695705Joy, K.L., N.V. Rajeshkumar, G. Kuttan and R. Kuttan,2000Picrorrhhiza kurroa extract on transplanted tumor and chemical carcinogenesis in mice.]]>71261266Ma, Y., T. Mizuno and H. Ito,1991Hohenbuehelia serotina.]]>5527012710Mary, K.T., K. Girija and K. Ramadasan,1994Helicanthis elasticus (Fam. Loranthaceae).]]>815357Mounetou, E., J. legault, J. Lacroix and R. Gaudreault,200144694702Murphy, P.V., R.E. Hubbard, D.T. Manallack, J.G. Mantana and J.K. Taylor,19983932733276Musa, D., N. Dilsiz, H. Gumushan, G. Ulakoglu and M. Bitiren,2004Nigella sativa seeds.]]>59735740Nabih, I., J. Michael, H. Zoroob and M.I. El-Zahar,198526311316Ohmo, K., S. Nakano, T. Kobayashi, Y. Nagao and T. Yamada,200241525555Prasad, S.B. and A. Giri,199432155162Prieur, D.J., D.M. Young, R.D. Davis, D.A. Cooney, E.R. Homan, R.L. Dixon and A.M. Guarino,19734139Rajeshwar, Y., M. Gupta and U.K. Mazumder,2005in vivo antioxidant status of Mucuna pruriens (Fabaceae) seeds against Ehrlich ascites carcinoma in Swiss albino mice.]]>44653Rashad, E.R. and M.A. Ali,2006251728Ronconi, L., L. Giovagnini, C. Marzano, F. Bettio, R. Graziani, G. Piloni and D. Fregona,2005in vitro antitumor activity.]]>4418671881Rauter, A.P., M. Padilha, J.A. Figueiredo, M.I. Ismael and J. Justino et al.,200524275296Sayed, H.H., A.H. Shamroukh and A.E. Rashad,200656231244Shigeta, S.H., S. Mori, F. Watanabe, T. Takahashi, N. Nagata, T. Koike, T. Wakayama and M. Sanyoshi,2002136782Shriram, D., P. Yogeeswari and K. Meena,200661274277Sondhi, S.M., N. Singhal, M. Jorhar, B.S.N. Reddy and W. Lown,2002910451074Tsuchiya, T., Y. Takagi and H. Yamada,200010203207