International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2006.47.49Strobilanthes crispus Extracts and its Compounds in vitro]]>RahmatAsmah EdriniSusi Md. AkimAbdah IsmailPatimah Yap Yun HinTaufiq Fadzelly Abu BakarMohd 1200621The antiproliferative activities of Strobilanthes crispus was evaluated using (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazoliumbromide) (MTT) assay against several cancer cell lines and Chang liver (normal) cell lines. The methanolic extracts of Strobilanthes crispus displayed the strongest cytotoxic effect on colon cancer (Caco-2) followed by human breast cancer hormone non-dependent (MDA-MB-231) and liver cancer (HepG-2) with IC50 values of 22.3, 27.2 and 29.3 μg mL-1, respectively. The chloroform extract of this plant was shown to also have cytotoxic effect against Caco-2 and HepG-2 with IC50 values of 25.1 and 28.0 μg mL-1, respectively. β-sitosterol and stigmasterol were isolated from the leaves of Strobilanthes crispus. β-sitosterol displayed cytotoxic properties against Caco-2, HepG-2 and MCF-7 with IC50 values of 20.0, 53.0 and 71.2 μM, respectively. Whereas, stigmasterol inhibited the proliferation of Caco2, HepG2, MCF-7 and MDA-MB-231 with IC50 values of 132.5, 182.5, 156.0 and 185.9 μM, respectively. There was no cytotoxic effect observed on normal cell lines (Chang liver) in all samples tested.]]>Ali, A.M., M. Macjen, M. Hamid, I. Safinar, N.H. Lajis, S. El-Sharkawy and M. Murakoshi,1996Juniperus chinensis.]]>53165169Hara, Y.,19941994pp: 34-50pp: 34-50Ismail, M., E. Manickam, M.A. Danial, A. Rahmat and A. Yahaya,2000Strobilanthes crispus leaf extract.]]>11536542Jaksa, S., A. Rahmat, F. Othman, P. ismail and S.M. Mansor,2004Strobilanthes crispus leaf extract on liver histology and enzymes changes in rats.]]>5187192Kusumoto, J.T., I. Shimada, N. Kakiuchi, M. Hattori, S. Supriyatna and T. Namba,19926241244Soediro, I., J. Pellecuer, C. Andary and G. Privat,1983Strobilanthes crispus (L.) B1 I: Pemeriksaan senyawaan turunan asam kafeat verbascosid.]]>8110Soediro, I., J. Pellecuer, C. Andary and G. Privat,1987Strobilanthes crispus (L.) B1 I: Pemeriksaan asam fenolat.]]>XII17Sunarto, P.A.,19771st Edn.,pp: 95-99pp: 95-99