International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2006.267.276MoorthyN.S.H.N. TrivediP. 3200623In pursuit of effective anticancer molecules that can overcome resistance problems, a series of cytotoxic N10 substituted 2-methoxy acridone analogues were subjected to quantitative structure activity relationship analysis employing 2D molecular descriptors calculated from QSAR software Dragon. Multiple linear regression analysis of the data following a stepwise technique resulted in statistically significant triparametric models with good predictive power (r>0.9, q2>0.8). The results of the study suggest that flexibility of substituent sidechain and four membered methylene bridges between the acridone nucleus and substituents enhances the cytotoxic potency of 2 methoxy acridones. Further, the generated QSAR models also indicate that bulky substituents and the presence of sulfur atoms are disfavored whereas heteroatoms in the molecular extremity are favored for cytotoxic activity.]]>Adams, A., 2002916671675Chemoffice, C.S.,2001Demeunynck, M., 2004145570Demeunynck, M., F. Charmantray and A. Martelli, 2001717031724Denny, W.A., 1997618451852Denny, W.A., 2002916551665Durbin, J. and G. Watson,195037409428Durbin, J. and G. S. Watson,195138159178Karelson, M., V.S. Lobanov and A.R. Katritzky,19969610271044Krishnagowda, G., P. Thimmaiah, R. Hegde, C. Dass, P.J. Houghton and K.N. Thimmaiah, 20021023672380Mazerska, Z., E. Augustin, J. Dziegielewski, M.W. Cholody and J. Konopa, 1996in vivo and in vitro tests. ]]>117388Read, M., R.J. Harrison, B. Romagnoli, F.A. Tanious and S.H. Gowan et al., 20019848444849Schultz, H.P. E.B. Schultz and T.P. Schultz, 19943411511157Sharma, V., R. Goswami and A.K. Madan, 199737273282Wiener, H.,1947691720