International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2006.176.187MocellinSimone 2200622Given its pivotal role in growth and survival, the tumor vasculature represents an attractive target for anticancer therapy. Over the last few decades, rapid progress has been achieved in the understanding of tumor angiogenesis including signaling pathways and their regulation. This has enabled the development of numerous potentially effective vasculature-targeted anticancer drugs (VTAD), which are being tested in the clinical setting. In this review I will focus on the most promising and advanced drugs targeting the tumor vasculature, briefly summarizing their mechanism of action and the clinical results so far obtained.]]>Altorki, N.K., R.S. Keresztes, J.L. Port, D.M. Libby and R.J. Korst et al.,20032126452650Arora, A. and E.M. Scholar,2005315971979Bergsland, E.K.,2004611220Bilenker, J.H., K.T. Flaherty, M. Rosen, L. Davis and M. Gallagher et al.,20051115271533Carmeliet, P.,20039653660Clark, J.W., J.P. Eder, D. Ryan, C. Lathia and H.J. Lenz,20051154725480Eder, Jr. J.P., J.G. Supko, J.W. Clark, T.A. Puchalski and R. Garcia-Carbonero et al.,20022037723784Eskens, F.A., H. Dumez, R. Hoekstra, A. Perschl and C. Brindley et al.,200339917926Fayette, J., J.C. Soria and J.P. Armand,20054111091116Ferrara, N., H.P. Gerber and J. LeCouter,20039669676Folberg, R., M.J. Hendrix and A.J. Maniotis,2000156361381Hoekstra, R., F.Y. de Vos, F.A. Eskens, J.A. Gietema and A. Van der Gaast et al.,20052351885197Hurwitz, H., L. Fehrenbacher, W. Novotny, T. Cartwright and J. Hainsworth et al.,200435023352342Jimeno, J., J.A. Lopez-Martin, A. Ruiz-Casado, M.A. Izquierdo, P.J. Scheuer and K. Rinehart,200415321329Kamiyama, M., Y. Ichikawa, T. Ishikawa, T. Chishima and S. Hasegawa et al.,20029197201Kim, K.J., B. Li, J. Winer, M. Armanini, N. Gillett, H.S. Phillips and N. Ferrara,1993in vivo.]]>362841844Kindler, H.L., G. Friberg, D.A. Singh, G. Locker and S. Nattam et al.,20052380338040Klagsbrun, M. and A. Eichmann,200516535548Kuenen, B.C., G. Giaccone, R. Ruijter, A. Kok and C. Schalkwijk et al.,20051162406246Lyden, D., K. Hattori, S. Dias, C. Costa and P. Blaikie et al.,2001711941201McNeel, D.G., J. Eickhoff, F.T. Lee, D.M. King and D. Alberti et al.,20051178517860Niederman, T.M., Z. Ghogawala, B.S. Carter, H.S. Tompkins, M.M. Russell and R.C. Mulligan,20029970097014Peters, B.A., L.A. Diaz, K. Polyak, L. Meszler and K. Romans et al.,200511261262Posey, J.A., T.C. Ng, B. Yang, M.B. Khazaeli and M.D. Carpenter et al.,2003913231332Pruthi, R.S., J.E. Derksen and D. Moore,200493275278Stevenson, J.P., M. Rosen, W. Sun, M. Gallagher and D.G. Haller et al.,20032144284438Sund, M., Y. Hamano, H. Sugimoto, A. Sudhakar and M. Soubasakos et al.,200510229342939Tortora, G., D. Melisi and F. Ciardiello,2004101126Weng, D.E., P.A. Masci, S.F. Radka, T.E. Jackson and P.A. Weiss et al.,20054948955Yancopoulos, G.D., S. Davis, N.W. Gale, J.S. Rudge, S.J. Wiegand and J. Holash,2000407242248Yang, J.C., L. Haworth, R.M. Sherry, P. Hwu and D.J. Schwartzentruber et al.,2003349427434Zakarija, A. and G. Soff,200517578583Mancuso, A. and C.N. Sternberg,200516670