International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2005.60.70SaleS. R.G. Tunstall GarceaG. 1200511To review the evidence for using of polyphenolic phytochemicals as cancer chemopreventive agents. A literature search was undertaken from 1963 to the present day, using Medline and Pubmed. Epidemiological data suggests that diets rich in polyphenols confer significant protection against the risk of colorectal cancer. These observations are supported by in vitro and in vivo data. Polyphenols are polymechanistic in their anti-cancer action, but a common mechanism to all is their anti-oxidant property. Poor bioavailability, however, is potentially a limiting factor to their further development as clinical agents. Data regarding the chemopreventive efficacy of polyphenolic compounds is growing. Clinical trial data, although limited, suggests that such compounds show great potential for use as chemopreventive agents. 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