International Journal of Biological Chemistry1819-155x2152-2561Science International10.3923/ijbc.2010.10.18Telfairia occidentalis Ameliorates Oxidative Brain Damage in Malnorished Rats]]>KayodeA.A.A. KayodeO.T. OdetolaA.A. 1201041It has been observed and established that enhancing the antioxidant defense system during the early phase of rehabilitation is important to the survival of wasting protein energy malnourished patients. In this study, comparison was made between the efficacy of dietary protein replenishment and supplementation with Telfairia occidentalis leaves, in the treatment of oxidative brain damage in the malnourished rats. The protein energy malnourished rats were produced by feeding weanling rats a protein deficient diet (2% protein) for 28 days. The malnourished rats were then divided into three dietary treatment groups, 20% protein+10% T. occidentalis group (PTG), 20% Protein Group (PG) and the 10% T. occidentalis group (TG). Significant decrease in brain size (p<0.01), activity of superoxide dismutase (p<0.01), catalase (p<0.01) and increased Malondialdehyde levels (p<0.01), indicative of oxidative damage were observed in the malnourished rats as compared with the control group. Reduced level of oxidative damage was however observed in group TG, PG and PTG , respectively. The result indicates that T. occidentalis leaves supplementation with protein repletion is more effective for recovery from protein energy malnutrition induced oxidative damage in rats than protein repletion alone.]]>Aderibigbe, A.O., B.A. Lawal and J.O. Oluwagbemi,1999Telfairia occidentalis in mice.]]>28171175Andrew-Lin, M.D.,20032003Ashour, M.N., S.I. Salem, H.M.E. Gadban, N.M. Elwan and T.K. Basu,199953669673Child, R., S. Brown, S. Day, A. Donnelly, H. Roper and J. Saxton,199996105115Egbekun, M.K., E.O. Nda-Suleiman and O. Akinyeye,1998Telfairia occidentalis) in marmalade manufacturing.]]>52171176Fernanda, B., M. Polydoro, M.E. Andrades, M. Luiz and F. Dal-Pizzol et al.,2006406281284Giami, S.Y. and L.I. Barber,2004Telfairia occidentalis Hook) seeds in cookie formulations.]]>8419011907Gilbert, D.L.,1981pp: 1-43pp: 1-43Hamidu, J.L., H.A. Salami, A.U. Ekanem and L. Hamman,20036123127Harper, A.E., N.J. Benevenga and R.M. Wohlhueter,197050428558Horsfall, M. and I.A. Spiff,20053+, Co2+ and Ag+ in aqueous solutions by fluted pumpkin (Telfairia occidentalis HOOK f) waste biomass.]]>52174181Jimoh, F.O., A.A. Odutuga and A.T. Oladiji,20054431434Kayode, O.T., A.A. Kayode and A.A. Odetola,200938092Keusch, G.T. and M.J.G. Farthing,19866131154Magwere, T., Y.S. Naik and J.A. Hasler,199722321327Manary, M.J. and D.R. Brewster,199724194201Misra, H.P. and I. Fridovich,197224731703175Oboh, G.,2005Telfairia occidentalis) leaves against garlic-induced oxidative stress.]]>8560563Okoli, B.E. and B.L. Nyananyo,1988Telfairia L. (Cucurbitaceae).]]>23281283Ramdath D.D. and M.H.N. Golden,199347658665Sinha, A.K.,197143468471Tuula, E.,199510149164Valko, M., D. Leibfritz, J. Moncol, M.T.D. Cronin, M. Mazur and J. Telser,2007394484Varshney, R. and R.K. Kale,199058733743Weighand, M.A., A. Laipple and K. Plascke,199930306311World Health Organization,2006Yusuf, H.K.M., Z. Haque and Z. Mozaffar,198136924930