International Journal of Biological Chemistry1819-155x2152-2561Science International10.3923/ijbc.2008.42.48Parkinsonia aculeataL. Against CCl4 Intoxication in Albino Rats]]>HassanS.W. UmarR.A. EbboA.A. AkpejiA.J. MatazuI.K. 2200822Hepatoprotective activity of 50% ethanolic leaf extracts
of Parkinsonia aculeata was evaluated against carbon tetrachloride
(CCl4)-induced hepatic damage in rats. The extract at doses
of 100, 200 and 300 mg kg-1 body weight were administered orally
once daily. Hepatoprotective activity was measured based on biochemical
parameters. Significantly (p<0.05) elevated levels of aspartate transaminase
(AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin
(TB) and peroxide value in CCl4-intoxicated rats were restored
to normal levels in the animals treated with the extract at doses of 100,
200 and 300 mg kg-1 and CCl4. The levels of total
proteins, albumin, vitamins C and E appreciated significantly (p<0.05)
in animals treated with different doses of the leaf extracts and CCl4.
The effects were dose-dependant. These results suggest the leaf extracts
of this plant to have potential therapeutic and preventive efficacies,
probably due to its antioxidative effect. ]]>Achliya, G.S., S.G. Wadodkar and A.K. Dorle,200490229232Ahmed, S., A. Rahman, A. Alam, M. Saleem, M. Athar and S. Sultana,2000Lawsonia alba in the alleviation of carbon tetrachloride-induced oxidative stress.]]>69157164Aniagu, S.O., F.C. Nwinyi, B. Olanubi, D.D. Akumka and G.A. Ajoku et al.,2004Berlina grandiflora (Leguminosae) toxic in rats?]]>11352360Shenoy, K.A., S.N. Somayaji and K.L. Bairy,2002Gingo biloba in rats.]]>46167174Auddy, B., M. Ferreira, F. Blasina, L. Lafon and F. Arredondo et al.,200384131138Jain, A., M. Soni, L. Deb, A. Jain, S.P. Rout, V.B. Gupta and K.L. Krishna,2008Momordica dioica Roxb. leaves.]]>1156166Baker, H., O. Frank, B. Angelis and S. Feingold,198021531536Chatterjee, T.K.,2000Vol. 3.,pp: 135pp: 135Chattopadhyay, R.R.,2003Azadirachta indica leaf extract: Part II.]]>89217219Cheesbrough, M.,19912nd Edn.,pp: 473-474pp: 473-474Choi, C.W., S.C. Kim, S.S. Hwang, B.K. Choi and H.J. Ahn et al.,200216311611168Di Carlo, G., N. Mascolo, A.A. Izzo and F. Capasso,199965337353Department of Natural Resources,1998Parkinsonia aculeata.]]>1998Formica, J.V. and W. Regelson,19953310611080Gornall, A.G., C.J. Bardawill and M.M. David,1949177751766Rao, G.M.M., C.V. Rao, P. Pushpangadan and A. Shirwaikar,2006Rubia cordifolia Linn.]]>103484490Gupta, M., U.K. Mazumder, T.S. Kumar, P. Gomathi and R.S. Kumar,2004Buhinia racemosa against paracetamol and carbon tetrachloride induced liver damage in rats.]]>31220Hassan, S.W., R.A. Umar, A.A. Ebbo and I.K. Matazu,2005Parkinsonia aculeata L. (Fabaceae).]]>208997El Hilaly, J., Z.H. Israili and B. Lyoussi,2004Ajuga iva in experimental animals.]]>914350Kumar, G., G. Sharmila Banu, P. Vanitha Pappa, M. Sundararajan and M. Rajasekara Pandian,2004Trianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats.]]>923740Kupeli, E., D.D. Orhan and E. Yesilada,2006Citrus laurifolius L. leaf extracts and flavonoids on acetaminophen-induced hepatotoxicity in mice.]]>103455460Leite, A.C.R., T.G. Araujo, B.M. Carvalho, N.H. Silva, V.L.M. Lima and M.B.S. Maia,2007Parkinsonia aculeata aqueous extract fraction: Biochemical studies in alloxan-induced diabetic rats.]]>111547552Mantle, D., F. Eddeb and A.T. Pickering,2000in vitro.]]>724751Niko, R., S.J. Vesna, S. Gordana, S. Andrija, S. Michael and A. Yoshinori,2007in vitro antimicrobial and antioxidant activity of nine Hypericum species from the Balkans.]]>1031521Rec GSCC,197210182182Reitman, S. and S. Frankel,1957285663Record, I.R., J.K. McInerney and I.E. Dreosti,1996532743Sanmugapriya, E. and S. Venkataraman,2006Strychnos potatorum Linn. seeds on CCl4-induced acute hepatic injury in experimental rats.]]>105154160Singh, B., A.K. Saxena, B.K. Chandan, K.K. Anand, O.P. Suri, K.A. Suri and N.K. Satti,199859135140Tolman, K.G. and R. Rej,19991999pp: 1125-1177pp: 1125-1177Urbach, C., K. Hickman and P.L. Harris,195110720Varley, H., A.H. Gewenlock and M. Bell,19915th Edn.,pp: 741-742pp: 741-742Wongnawa, M., P. Thaina, N. Bumrungwong, P. Rattanapirun and A. Nitiruangjaras et al.,200628551561Zimmerman, M.,198316109110Ohkawa, H., N. Ohishi and K. Yagi,197995351358