International Journal of Botany1811-97001811-9719Asian Network for Scientific Information10.3923/ijb.2015.21.26Terminalia chebula by Hydrogen Peroxide Induced Oxidative Stress in THP-1 Cell Line]]>MinakshiG.C. VasanthK. Tanupriya IlangoK. AgrawalAruna DubeyG.P. 12015111Diseases caused due to oxidative stress initiated by Reactive Oxygen Species (ROS) is growing at an alarming rate. Several medicinal herbs explored till date were reported to possess numerous pharmacological properties used for combating different diseases. The present study was undertaken to investigate the inhibitory potential of Terminalia chebula by H2O2 induced oxidative stress in THP-1 cell line and also the presence of the marker compounds in T. chebula was confirmed by High Performance Liquid Chromatography (HPLC). Intracellular quantification of ROS was done using a flow cytometer. The percentage of gallic acid and ellagic acid in the extract was performed by HPLC were found to be 4.84% w/w and 2.56% w/w, respectively. Pretreatment of cells with T. chebula extract significantly reduced the intracellular ROS production in a dose-dependent manner. The present study illustrates the effective role of T. chebula in reducing the ROS production which is a causative factor for several disorders. The results describe the possibility and potentiality of natural sources to inhibit the pathogenesis of different diseases caused due to oxidative stress.]]>Bag, A., S.K. Bhattacharyya and R.R. Chattopadhyay,2013Terminalia chebula Retz. (Combretaceae) in clinical research.]]>3244252Chanput, W., J.J. Mes and H.J. Wichers,2014in vitro cell model for immune modulation approach.]]>233745Chen, X., F. Sun, L. Ma, J. Wang, H. Qin and G. Du,2011In vitro evaluation on the antioxidant capacity of triethylchebulate, an aglycone from Terminalia chebula retz fruit.]]>43320323Cheng, H.Y., T.C. Lin, K.H. Yu, C.M. Yang and C.C. Lin,2003Terminalia chebula.]]>2613311335Garcia-Nino, W.R. and C. Zazueta,20159784103Gusman, G.S., P.R. Campana, L.C. Castro, R.O. Castilho, M.M. Teixeira and F.C. Braga,20152015Kam, A., K.M. Li, V. Razmovski-Naumovski, S. Nammi, K. Chan and G.Q. Li,2014171231242Kathirvel, A. and V. Sujatha,2012In vitro assessment of antioxidant and antibacterial properties of Terminalia chebula retz. leaves.]]>2S788S795Krejsa, C.M. and G.L. Schieven,2000993547Lee, H.H., K.R. Paudel and D.W. Kim,2015Terminalia chebula fructus inhibits migration and proliferation of vascular smooth muscle cells and production of inflammatory mediators in RAW 264.7.]]>2015Lee, W.J., H.C. Ou, W.C. Hsu, M.M. Chou and J.J. Tseng et al.,20105212901300Lin, L.T., W.C. Hsu and C.C. Lin,201442435Lv, L., L. Zheng, D. Dong, L. Xu and L. Yin et al.,201359657669Maddinedi, S.B., B.K. Mandal, R. Vankayala, P. Kalluru and S.R. Pamanji,2015Terminalia chebula seeds extract.]]>145117124Mathew, M. and S. Subramanian,2014In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders.]]>2014Rekha, V., Jayamathi, RamaKrishnan, D. Vijayalakshmi and Prabu et al.,2014Terminalia chebula.]]>8ZC51ZC54Saha, S. and R.J. Verma,2016Terminalia chebula retzius fruits.]]>2016Sham, T.T., C.O. Chan, Y.H. Wang, J.M. Yang, D.K. Mok and S.W. Chan,20142014Singhal, M., A. Paul and H.P. Singh,201418121127Subramanian, V., B. Venkatesan, A. Tumala and E. Vellaichamy,2014664455Vasanth, K., K. Ilango, R. MohanKumar, A. Agrawal and G.P. Dubey,2014Moringa oleifera mediated silver nanoparticles on human cervical carcinoma cells by apoptosis induction.]]>117354359Wang, J., J.R. Du, Y. Wang, X. Kuang and C.Y. Wang,201031791797