International Journal of Botany1811-97001811-9719Asian Network for Scientific Information10.3923/ijb.2011.300.304In vitro Cytotoxic Evaluation of Hugonia mystax Linn. Leaf and Stem Bark Extracts]]>AnandakumarSingaram KarmegamNatchimuthu 4201174In the present study, the methanol extracts of Hugonia mystax Linn. leaves and stem bark were tested for cytotoxic effect against three different human cancer cell lines, HeLa cervical cancer cell line, MCF-7 human breast adenocarcinoma cell line and A-549 human lung adenocarcinoma epithelial cell line, in comparison with normal vero cell line by MTT assay. Results revealed that the methanolic extracts of leaves stem bark exhibited cytotoxicity towards the cancerous cell lines. CTC50 concentration of 228.12, 181.01, 343.75 and 875.0 μg mL-1 against HeLa, MCF-7, A-549 and vero cell lines was recorded. Methanolic stem bark extract showed the lower CTC50 concentration against HeLa and MCF-7 cell lines and higher CTC50 concentration against A-549 and vero cell lines. The results indicated us the feasible anticancer nature of the leaf and bark methanolic crude extracts of H. mystax.]]>Aini, N.A.S., A. Merrina, J. Stanslas and S. Sreeramanan,20084103109Aisha, A.F.A., Z.D. Nassar, M.J. Siddiqui, K.M. Abu-Salah, S.A. Alrokayan, Z. Ismail and A.M.S.A. Majid,2011Syzygium aromaticum L. extracts.]]>4282290Bisht, V.K., J.S. Negi, A.K. Bhandari and R.C. Sundriyal,20117192208Duker-Eshun, G., J.W. Jaroszewski, W.A. Asomaning, F. Oppong-Boachie and S.B. Christensen,2004Cajanus cajan.]]>18128130Denizot, F. and R. Lang,198689271277Gansane, A., S. Sanon, P.L. Ouattara, S. Hutter and E. Ollivier et al.,2010Zanthoxylum zanthoxyloides Lam. Bark of Trunk.]]>6921925Hafidh, R.R., F. Abas, A.S. Abdulamir, F. Jahanshiri, F. Abu Bakar and Z. Sekawi,200956982Halliwell, B. and J.M. Gutteridge,1984219114Hutchings, A.,1996Pages: 450Pages: 450Konuklugi, B.,1996Hugonia tomentosa.]]>34390392Matsukawa, Y., N. Marui, T. Sakai, Y. Satomi and M. Yoshida et al.,19935313281331Meyer, B.N., N.R. Ferrigni, J.E. Putnam, L.B. Jacobsen, D.E. Nichols and J.L. Mclaughlin,1982453134Rafter, J.J.,200288S219S224Rajeshwar, Y., M. Gupta and U.K. Mazumder,2005in vivo antioxidant status of Mucuna pruriens (Fabaceae) seeds against Ehrlich ascites carcinoma in Swiss albino mice.]]>44653Saha, P., S.K. Sen, A. Bala, U.K. Mazumder and P.K. Haldar,2011Lagenaria siceraria aerial parts.]]>7244253Siddiqui, M.J., Z. Ismail, A.F.A. Aisha and A.M.S. Abdul Majid,2010Catharanthus roseus (Apocynaceae) crude extracts and pure compounds against human colorectal carcinoma cell line.]]>64347Sunilson, J.A.J., G. Rejitha, K. Anandarajagopal, A. Das, M. Muthappan and P. Promwichit,2009Cayratia carnosa leaves on human breast cancer cell lines.]]>5115122Uddin, K., A. Sayeed, A. Islam, A.A. Rahman, A. Ali, G.R.M.A.M. Khan and M.G. Sadik,2003Oroxylum indicum vent. (Bignoniaceae).]]>2515518