European Journal of Dentistry and Medicine1996-3378xxxx-xxxxAcademic Journals Inc.10.3923/ejdm.2017.1.8RajputDaxa IshnavaKalpesh 1201791Background and Objective: Today, dental caries is still one of the most common diseases in the world. The causes of tooth decay in most cases are the poor oral hygiene and high sugar consumption. Despite several dental caries agents being available in the market, the search for an effective agent still continues. Several undesirable side effects associated with these agents stimulated the search for alternate agents. The objective of this study was than to investigate the inhibitory effect of the crude seed extracts from some traditional medicinal plants on anticariogenic organisms under in vitro condition for their use for controlling dental caries. Attempt was also made to characterize bioactive compound at primary level. Materials and Methods: The anticariogenic activity was assessed by agar well diffusion method. MIC against six dental microorganisms and the radial zone of inhibition was measured. Phytochemical evaluation of all the selected plants showed good MIC values and TLC-Bioautography. The data was statistically analyzed by one way analysis of variance (ANOVA) using SPSS ver. 16.0. Results: The results revealed that the hexane extract of plant seeds has more potent anticariogenic activities against oral microorganisms. Maximum zone of inhibition (18 mm) was found when seed extracts of Mimusops elengi L. tested against Candida albicans. The MIC of hexane extract of Mimusops elengi L. and Punica granatum L. seed against CA and SP was 0.075 and 0.3, respectively. The MIC value of 0.3 was found for SP using Punica granatum L. The result of bioautography showed that the compound was active against Candida albicans and Streptococcus pyogenes. Conclusion: Hence, the study concludes that the very good activity of methanol extract of seed of Mimusops elengi L. and Punica granatum L. will be useful in the future development of effective toothpaste or mouth washer against oral microorganisms.]]>Cho, Y.S., N.L. Schiller, H.Y. Kahng and K.H. Oh,2007Escherichia coli exposed to green tea polyphenols.]]>55501506Loesche, W.,200721471502Barad, M.K., K.B. Ishnava and J.B. Chauhan,201438590Devi, B.P. and R. Ramasubramaniaraja,2009216691675Parekh, J. and S.V. Chanda,2007In vitro antimicrobial activity and phytochemical analysis of some Indian medicinal plants.]]>315358SPSS.,2007Omwenga, E.O., P.O. Okemo, P.K. Mbugua and C. Ogol,20095165175Tullanithi, K.M., B. Sharmila and T.S. Gnanendra,2010Achyranthes aspera Linn.]]>13538Arya, V., S. Yadav, S. Kumar and J.P. Yadav,2010Cassia occidentalis L. (Leaf) against various human pathogenic microbes.]]>2010111Rahmatullah, M., A. Momen, M. Rahman, D. Nasrin and S. Hossain et al.,2010499105Rao, P.K., M. Anjana, L. Deepti, K. Madhavi and T.R. Rao,2009In vitro antibacterial screening of selected medicinal plant extracts against oral pathogens.]]>23479485Anand, T.D., C. Pothiraj, R.M. Gopinath and B. Kayalvizhi,200826366Sabale, V., V. Patel, A. Paranjape, C. Arya, S.N. Sakarkar and P.M. Sabale,2008Moringa oleifera (Drumstick): An overview.]]>2713Mastan, S.A., P.J. Ramayya, L.M. Naidu and K. Mallikarjuna,2009Mucuna pruriens leaves.]]>25560Badgujar, S.B., R.T. Mahajan and S.B. Kosalge,20081211371144Chanda, S., M. Kaneria and R. Nair,2011Psoralea corylifolia L. seed and aerial parts with various extraction methods.]]>60124131Devi, A., V. Singh and A.B. Bhatt,2011Punica granatum.]]>2504508Asokan, S., J. Rathan, M.S. Muthu, V.P. Rathna, P. Emmadi, Raghuraman and Chamundeswar,2008Streptococcus mutans count in plaque and saliva using Dentocult SM Strip mutans test: A randomized, controlled, triple-blind study.]]>261217