Current Research in Chemistry1996-50522152-3385xAsian Network for Scientific Information10.3923/crc.2012.76.87AroraRashmi KaurAmandeep GillNaresh Singh 4201244A novel series of pyrazole derivatives of benzimidazole was synthesized by
the reaction between o-phenylenediamine and equimolar quantities of lactic acid.
The products obtained were treated with phenylhydrazine in the presence of ethanolic
sodium acetate to synthesize various pyrazole derivatives of benzimidazole i.e.,
2-[5-(4-chloro-phenyl-2H-pyrazol-3-yl]-1H-benzimidazole (1a), 2-[5-(3-bromo-phenyl)-2-phenyl-2H-pyrazol-3-yl]-1H-benzimidazole
(1b), {4-[5-(1H-benzimidazol-2-yl)-1-phenyl-1H-pyrazol-3yl]-phenyl}-dimethyl-amine
(1c), 2-[5-(3-Chloro-phenyl)-2-phenyl-2H-pyrazol-3-yl]-1H-benzimidazole (1d)
and 3-[5-(1H-benzimidazol-2-yl)-1-phenyl-1h-pyrazol-3-yl]-phenol (1e) having
%age yield 55, 62, 80, 58, 66, respectively. The structures of these compounds
were established by IR, 1H-NMR and elemental analysis. The synthesized
Compounds was evaluated for analgesic as well as anti-inflammatory activity.
The compound 1a-1e showed significant analgesic activity at 7.36±0.05,
7.50±0.08, 8.43±0.12, 7.88±0.02 and 7.64±0.08 at
90 min when compared with standard i.e., 9.45±0.28 at 90 min, respectively.
Further the compounds 1a-1e were evaluated for anti-inflammatory activity and
showed significant % inhibition of edema i.e., 59.09, 63.63, 62, 60.60 and 57.57%
at a dose of 200 mg mL-1 as compared to standard drug i.e., 69.6%
at 3 h, respectively. The compound 1b showed significant anti-inflammatory where
as compound 1c showed potent analgesic activity and the other compounds showed
moderate activity. This comprehensive study summarizes the different pyrazole
derivatives of benzimidazole were showed excellent significant analgesic and
anti-inflammatory activities.]]>Rao, A., A. Chimirri, S. Ferro, A.M. Monforte, P. Monforte and M. Zappala,20045147155Kalirajan, R., L. Rathore, S. Jubie, B. Gowramma, S. Gomathy, S. Sankar and K. Elango,201044358362Thakurdesai, P.A., S.G. Wadodkar and C.T. Chopade,20071314329Sreena, K., R. Ratheesh, M. Rachana, M. Poomima and C. Shyni,200912122Patil, A., S. Ganguly and S. Surana,20081447460Ghorab, M.M., H.I. Heiba, A.A. Hassan, A.B. Abd El-Aziz and M.G. El-Gazzar,2011710631073Mohamed, G.B., M.A. Hussein, A.M. Abdel-Alim and M. Hashem,2006292633Arunkumar, S., K. Ilango, R.S. Manikandan and N. Ramalakshmi,20096S123S128Turan-Zitouni, G., Z.A. Kaplancikli, K. Erol and F.S. Kilic,199954218223Ansari, K.F. and C. Lal,200912110171025Bhaskar, V.H. and P.B. Mohite,20103716Anandarajangopal, K., R.N. Tiwari, N. Venkateshan, G.V. Pooshan and P. Promwichit,20102230236Dubois, R.W., G.Y. Melmed, J.M. Henning and L. Laine,200419197208Soni, J.P., D.J. Sen and K.M. Modh,20111115120Kaliranjan, R., R. Leela, S. Jubie, B. Gowramma, S. Gomathy and S. Shakar,201150B17941799Kota, R.K., K.K. Kompelly, R. Surampudi and R. Kulakarni,20113848853Hussain, S., D. Kaushik and M. Sharma,20105257263Mohan, V.G., N. Sreenivasulu, A.S. Rao and S. Chigiri,20113446452Mariappan, G., N.R. Bhuyan, P. Kumar, D. Kumar and K. Murali,201150B12161219Achar, K.C.S., K.M. Hosamani and H.R. Seetharamareddy,2010In vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives.]]>4520482054Shukla, A.,20123922927Eddy, N.B. and D. Leimback,1953107385393