Biotechnology1682-296x1682-2978Asian Network for Scientific Information10.3923/biotech.2007.210.217Candida albicans]]>Abu SiniMohammad K.Abu-ElteenKhaled H.ElkarmiAli Z.HamadMawieh A.KhuzaieRula F.2200762The effect of pretreatment of Candida albicans with different UV light (360 nm) intensities (4, 6 and 10 W m-2) at different time intervals (6, 12, 24 and 48 h) in an attempt to investigate its influence on proteinase and phospholipase activities in correlation with in vitro adherence to Buccal Epithelial Cells (BECs) and lethality to mice were studied. Irradiated C. albicans cells were found to be less virulent than non-irradiated. Exposure of C. albicans to various doses of radiation led to a reduction in adherence between 6.8 and 66.7% of the control value. This reduction was dose intensity and time related. The secretion of extracellular proteinase and phospholipase was also reduced to statistically significant between irradiated and non-irradiated C. albicans. 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