Asian Journal of Scientific Research1992-14542077-2076Asian Network for Scientific Information10.3923/ajsr.2009.87.95b-poly (D, L-lactide-co-glycolide) Films as Drug Delivery Systems for Ibuprofen]]>BaimarkY. PhromsophaT. 2200922Methoxy poly (ethylene glycol)-b-poly (D,L-lactide-co-glycolide) diblock copolymers (MPEG-b-PDLLG) films containing a poorly water-soluble drug were prepared by evaporation method of MPEG-b-PDLLG and drug solution in dichloromethane. Ibuprofen was used as a poorly water-insoluble model drug. Influences of MPEG block length and DLL/G ratio on drug-loaded film character and drug release behavior were investigated. Inhibition of entrapped ibuprofen crystallization in the MPEG-b-PDLLG films was observed from thermal analysis. The drug release rates increased as the MPEG block length increased. Incorporation of G units in the PDLL block also induced the faster drug release rate. The drug had released from the films through diffusion mechanism.]]>Baimark, Y., M. Srisa-ard, J. Threeprom, R. Molloy and W. Punyodom,200713819Beletsi, A., L. Leontiadis, P. Klepetsanis, D.S. Ithakissios and K. Avgoustakis,1999182187197Borovac, T., J.P. Pelage, A. Kasselouri, P. Prognon, G. Guiffant and A. Laurent,2006In vitro and in vivo studies.]]>115266274Edlund, U. and A.C. Albertsson,200215767112Houchin, M.L., S.A. Neuenswander and E.M. Topp,2007117413420Kim, S.Y., I.G. Shin and Y.M. Lee,199856197208Kim, S.Y., I.G. Chin and Y.M. Lee,19992010331042Kim, S.Y., Y.M. Lee and J.S. Kang,200574A581590Kister, G., G. Cassanas and M. Vert,19983933353340Ljungberg, N. and B. Wesslen,20034476797688Martin, O. and L. Averous,20014262096219Martino, V.P., R.A. Ruseckaite and A. Jimenez,200686707712Morakot, N., J. Threeprom and Y. Baimark, 2008b-poly(D,L-lactide-co-glycolide-co-e-caprolactone) films.]]>92111Ouchi, T., S. Ichimura and Y. Ohya,200647429434Plackett, D.V., V.K. Holm, P. Johansen, S. Ndoni, P.V. Nielsen, T. Sipilanien-Malm, A. Sodergard and S. Verstichel,200619124Ren, J., H. Hong, J. Song and T. Ren,20059818841890Thompson, C.J., D. Hansford, S. Higgins, C. Rostron, G.A. Hutcheon and D.L. Munday,20073295361Wang, Y., P. Challa, D.L. Epstein and F. Yuan,20042542794285Yuehuei, H.A.,2000in vivo evaluation of orthopaedic bioabsorbable devices.]]>2126352652Zurita, R., J. Puiggali and A. Rodriguez-Galan,20066767775Jacobs, C., Ph. Dubois, R. Jerome and Ph. Teyssie,19912430273034