Asian Journal of Scientific Research1992-14542077-2076Asian Network for Scientific Information10.3923/ajsr.2009.167.179AL-SaffarF.J. GanabadiS. YaakubH. FakuraziS. 4200924The objective of this study was to apply and compare
two different experimental osteoarthritis (OA) methods in the rat, namely:
Collagenase induced OA (CO) and Monosodium iodoacetate induced OA (MIA)
models. The assessment of OA development and progression were performed
through three different periods (2, 4 and 6 weeks). Intra-articular injection
of either 4 mg joint-1 CO type II or 3 mg joint-1
MIA, were administered to the adult male Sprague Dawley rats, into their
right knee joints. Evaluation of OA changes in the knees was achieved
with both histopathology score system and radiography approach. Gross
results revealed earliest changes such as swelling and redness of the
right knee joints of all rats injected with either CO or MIA. Joint dissection
revealed distinct thickening of the joint capsule in MIA-injected rats
than in CO group. Present finding revealed early development of radiographical
as well as histopathological changes in MIA injected group. However, both
OA injected groups resulted in a chronic joint degeneration, measured
by cellular changes, matrix degradation, subchondral changes and marginal
osteophyte formation. Present findings showed significantly higher histopathological
score in MIA injected group than those of CO in each of the three selected
periods for OA induction. In conclusion, present results demonstrated
that MIA can induce OA changes in a shorter period of time than CO in
the Sprague Dawley rat. Radiography approach could be a useful tool to
evaluate osteoarthritic changes in the knee joints.]]>Appleyard, R.C., D. Burkhardt, P. Ghosh, R. Read, M. Cake, M.V. Swain and G.A.C. Murrell,2003116577Beyreuther, B., N. Callizot and T. Stohr,20079R14R14Blom, A.B., L.E.M.L. van Peter, A.E.M. Holthuysen, P.M. van Kraan, J. Roth, N. van Rooijen and W.B. van Berg,200412627635Bove, S.E., S.L. Calcaterra, R.M. Brooker, C.M. Huber and R.E. Guzman et al.,200311821830Choi, J.H., J.H. Choi, D.Y. Kim, J.H. Yoon and H.Y. Youn et al.,200210471478Dumond, H., N. Presle, P. Pottie, S. Pacquelet and B. Terlain et al.,200412284295Fernihough, J., C. Gentry, M. Malcangio, A. Fox and J. Rediske et al.,20041128393Galois, L., S. Etienne, G. Laurent, A.W. Pinzano and C.C. Henrionnet et al.,200412779786Guzman, R.E., M.G. Evans, S. Bove, B. Morenko and K. Kilgore,200331619624Janusz, M.J., A.M. Bendele, K.K. Brown, Y.O. Taiwo, L. Hsieh and S.A. Heitmeyer,200210785791Kikuchi, T., T. Sakuta and T. Yamaguchi,19986177186Kobayashi, K., H. Mishima, F. Harwood, S. Hashimoto and T. Toyoguchi et al.,2002223941Kobayashi, K., R. Imaizumi, H. Sumichika, H. Tanaka, M. Goda, A. Fukunari and H. Komatsu,20036511951199Lee, S.W., W.T. Chung, S.M. Choi, K.T. Kim, K.S. Yoo and Y.H. Yoo,2005101294298McDougall, J.J.,20068220220Moore, E., A. Bendele, D. Thompson, A. Littau, K. Waggie, B. Reardon and J. Ellsworth,200513623631Moreland, L.W.,200355467Oakley, S.P., M.N. Lassere, I. PorteK, Z. Szomor and P. Ghosh et al.,200412667679Pelletier, J.P., J.M. Pelletier, R.D. Altman, L.G. Mnaymneh, D.S. Howell and J.F.Jr. Woessner,198326866874Pelletier, J.P., J.A.D. Battista, J.P. Raynauld, S. Wilhelm and J.M. Pelletier,1995in vivo effects of intraarticular corticosteroid injections on cartilage lesions, stromelysin, interleukin-1 and oncogene protein synthesis in experimental osteoarthritis.]]>72578586Pomonis, J.D., J.M. Boulet, S.L. Gottshall, S. Phillips, R. Sellers, T. Bunton and K. Walker,2005114339346Smith, G.N., E.A. Mickler, M.E. Albrecht, S.L. Myers and K.D. Brandt,200210321326Stoop, R., P. Buma, P.M. van der Kraan, A.P. Hollander and R.C. Billinghurst et al.,20019308315Taylor, P.M. and S.A. Robertson,20046313320Van der Kraan, P.M., E.L. Vitters, H.M. van Beuningen, L.B. van der Putte, W.B. van der Berg,1990711931Williams, V.S.,200727298303Witter, J. and R.A. Dionne,20046279281Young, A.A., M.M. Smith, S.M. Smith, M.A. Cake and P. Ghosh et al.,20057852861North American Veterinary Conference Orlando, Florida,19981998Hattori, K., K. Ikeuchi, Y. Morita and Y. Takakura,200573846