Asian Journal of Scientific Research1992-14542077-2076Asian Network for Scientific Information10.3923/ajsr.2009.135.145SiddiquiM.R. TariqA. AhmadA. ChaudharyM. ShrivastavaS.M. SinghR.K. 3200923Two simple, rapid and sensitive spectrophotometric methods have been proposed for the determination of milrinone in pharmaceutical formulations. The first method is based on the charge transfer complexation reaction of milrinone with 2, 3-Dichloro-5, 6-Dicyanobenzoquinone, DDQ while the second method is based on charge transfer reaction of milrinone with p-Chloranilic Acid (pCA). Under the optimized experimental conditions Beer's law is obeyed in the concentration range of 2-40 μg mL-1 for method A and 5-100, 2-40 μg mL-1 for method B. The recovery ranged from 100.06 -100.11 for method A and from 99.34 -99.97 for method B. The coefficient of correlation was found to be 0.9998 for A and 0.9999 for B and the detection limit for method A and method B was found to be 0.765 and 3.35, respectively. Both the methods have been applied to determination of milrinone in the pharmaceutical formulation. Results of the analysis are validated statistically.]]>Lehtonen, L.A., S. Antila and P.J. Pentikainen,200443187203Ooi, H. and W.S. Colucci,20012001pp: 901-932pp: 901-932Bailey, J.M., T.M. Hoffman, D.L. Wessel, D.P. Nelson and A.M. Atz et al.,2004314359Nguyen, A.Q., Y. Theoret, C. Chen, A. Denault and F. Varin,2009877657660Brocks, D.R., T.J. Spencer and A. Shayeganpour,20058124131Edelson, J., R.F. Koss, J.F. Baker and G.B. Park,1983276456462Oddie, C.J., G.P. Jackman and A. Bobik,1986374209214Wilson, T.D., M.D. Forde, A.V. Crain, L.J. Dombrowski and M.A. Joyce,19864322182220Akkerman, S.R., H. Zhang, R.E. Mullins and K. Yaughn,1999566368Mohammed, G.G., F.A.N. El-Dien and E.U. Farag,2006651119El-Zeany, B.A., A.A. Moustafa and N.F. Farid,200324775782Rahman, N. and S.N.H. Azmi,20001613531356Rahman, N. and M. Kashif,200560636643Rahman, N. and S.M. Haque,200833143El Ragehy, N.A., S.S. Abbas and S.Z. El-Khateeb,19973020452058Darwish, I.A.,2005549212220Hesham, S.,20082136144Hesham, S.,20096332340