Asian Journal of Plant Sciences1682-39741812-5697Asian Network for Scientific Information10.3923/ajps.2021.291.299Tephrosia bracteolata Leaves]]>Adejoh IdakwojiPrecious Elijah JoshuaParker AsomaduRita Onyekachukwu NjokuObioma Uzoma Chiletugo NwodoOkwesili Fred 22021202Background and Objective:Tephrosia bracteolata is a medicinal plant used traditionally for the treatment of diabetes mellitus. In this study, the anti-diabetic potentials, phytochemical and proximate composition of various extracts of Tephrosia bracteolata leaves were investigated. Materials and Methods: Extraction of pulverized leaves of Tephrosia bracteolata was done using water, ethanol, chloroform/methanol (2:1). The extracts were subjected to phytochemical and proximate analyses and acute toxicity studies using standard methods. The extracts were also studied for anti-diabetic activity using alloxan (150 mg kg1 i.p) model of diabetes. The extracts were administered to diabetic rats at dose levels of 250 and 500 mg kg1 p.o for 28 days during which Fasting Blood Sugar (FBS), food/water intake and bodyweight were monitored as indices of anti-diabetic activity. Results: Phenols, alkaloids, saponins, glycosides and flavonoids were present in varying proportions in the extracts. Varying proportions of the proximate constituents were also observed. An acute toxicity study revealed that the extracts were non-toxic up to a dose of 5000 mg kg1. The extracts produced significant (p<0.05) reduction in FBS, water and food intake, but no significant (p>0.05) effect on the body weight of the treated rats in comparison with the diabetic control. The ethanol extract produced a significantly (p<0.05) higher anti-diabetic effect than the other extracts. Conclusion: Ethanol extract of T. bracteolata leaves was observed to possess potent anti-diabetic effect compared to other extracts, indicating the relevance of ethanol for the extraction of the anti-diabetic principles in T. bracteolata leaves.]]>Ugochukwu, N.H., N.E. Babady, M. Cobourne and S.R. Gasset,2003Gongronema latifolium extracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats.]]>2815Scoppola, A., F.R. Montecchi, G. Mezinger and A. Lala, 2001156357361Nawata, K., M. Sohmiya, M. Kawaguchi and Y. Kato, 20045313951398Owu, D.U., A.B. Antai, K.H. Udofia, A.O. Obembe, K.O. Obasi and M.U. Eteng,200631575579Tiwari, B.K., K.B. Pandey, A.B. Abidi and S.I. Rizvi,20132013Ahmed, I. and B. Goldstein, 200624237246Andrade-Cetto, A., J. Becerra-Jimenez and R. Cardenas-Vazquez, 20081162732Randle, P.J., P.B. Garland, C.N. Hales and E.A. Newsholme,1963281785789WHO,19991999Marles, R.J. and N.R. Farnsworth,19952137189Patel, D.K., R. Kumar, D. Laloo and S. 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