Asian Journal of Plant Sciences1682-39741812-5697Asian Network for Scientific Information10.3923/ajps.2012.235.240Trichosanthes cucumerina Ethanolic Seeds Extract]]>GillN.S. MarwahNistha AroraRashmi BaliM. 52012115The present study was to investigate antioxidant, analgesic
and antiulcer effect of ethanolic seeds extract of Trichosanthes cucumerina.
Extraction was done by cold maceration method for 72 h using ethanol as solvent.
The preliminary phytochemical screening showed the presence of triterpenoids,
flavanoids and sterols. The antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl
(DPPH) radical scavenging method. The extract showed maximum scavenging activity
86.2% at 150 μg mL-1 by DPPH method as compared to standard
antioxidant ascorbic acid. Further extract was studied for antiulcer activity
by ethanol induced ulcer model and Non steroidal anti-inflammatory drugs induced
method and analgesic activity by Eddys
hot plate method. Ethanolic extract of Trichosanthes cucumerina cause
72.1 and 57.1% inhibition of ulcer in Non steroidal anti-inflammatory drugs
induced model and ethanol induced model at 500 mg kg-1. Result concluded
that Ethanolic extract of Trichosanthes cucumerina possess high antiulcer
activity which is due to high antioxidant activity and extract also showed potential
analgesic activity by Eddys
hot plate method.]]>Alam, S., M. Asad, S.M.B. Asdaq and V.S. Prasad,2009Momordica charantia L. in rats.]]>123464469Arawwawala, M., I. Thabrew, L. Arambewela, N. Fernado and L.D. Guruge,2011Trichosanthes cucumerina extracts.]]>2808812Aqil, F., I. Ahmad and Z. Mehmood,200630177183Banerjee, D., S. Chakrabarti, A.K. Hazra, S. Banerjee, J. Ray and B. Mukherjee,20087805810Bhalke, R.D., M.A. Giri, S.J. Anarthe and S.C. Pal,2010Sesbania grandiflora (LINN.).]]>2206208Siddalingappa, C.M., T. Rajesh, B.L. Kudagi, K. Krishnakanth and T.R. Sujith,2012Tinospora cordifolia.]]>2012Gill, N.S., M. Garg, R. Bansal, S. Sood, A. Muthuraman, M. Bali and P.D. Sharma,2009Cucumis sativum L. seed extract in rats.]]>1131138Gill, N.S., J. Bajwa, P. Sharma, K. Dhiman and S. Sood et al.,2011Cucumis melo seeds.]]>68289Gulcin, I., O.I. Kufrevioglu, M. Oktay and M.E. Buyukokuroglu,2004Urtica dioica L.).]]>90205215Hameed, M.A., F. Amir, K.Y. Chin and S. Fathima,2011Aegle marmelos.]]>29094Kirana, H. and B.P. Srinivasan,2008Trichosanthes cucumerina improves glucose tolerance and tissue glycogen in non insulin dependent diabetes mellitius induced rats.]]>40103106Khalaf, N.A., A.K. Shakya, A. Al-Othman, Z. El-Agbar and H. Farah,2008325155Kore, K.J., R.V. Shete, A.J. Patel and J.B. Kulkarni,2011Spinacia oleracia in rats.]]>1654661Kumar, S.S., B.R. Kumar and G.K. Mohan,2009Trichosanthes cucumerina Var cucumerina L. on carbon tetrachloride induced liver damage in rats.]]>123347350Kumar, S.S., B.R. Kumar and G.K. Mohan,2007Trichosanthes cucumerina on carbon tetrachloride induced liver damage in rats.]]>3461469Murthy, J.R., P. Nataraj and R. Meera,2012Trichosanthes cucumerina.]]>2327340Sagar, L.S, V.R. Mali, G.N. Zambare and S.L. Bodhankar,2012Trichosanthes cucumerina on doxorubicin induced carditoxicity in wistar rats.]]>19167172Nikajoo, L.T.,2009Pergularia Daemia (FORSK.) CHIOV.]]>13337Oktay, M., I. Gulcin and O.I. Kufrevioglu,2003in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts.]]>36263271Okokon, J.E., H.D. Akpan, E.E. Umoh and I.S. Ekaidem,2011Hippocratea Africana root extract.]]>24201205Rajan, S., S. Mahalakshmi, V.M. Deepa, K. Sathya, S. Shajitha and T. Hirunalasundari,2011Punica granatum fruit rind extracts.]]>38288Reddy, L.J., B. Jose, J.C. Anjana and T.N. Ruveena,2010Trichosanthes Cucumerina L. and Cassia didymobotrya Fres. leaves.]]>2153155Sandhya, S., K.R. Vinod, J.C. Sekhar, R. Aradhana and V.S. Nath,2010Tricosanthes cucumerina L.]]>15660Uchikoba , T., H. Yonezawa and M. Kaneda,1998Benincasa hispida var. Ryukyu.]]>4922152220Ukwe, C.V., C.M. Ubaka, M.O. Adibe, C.J. Okonkwo and P.A. Akah,2010Zapoteca portoricensis (Fam. Fabiaceae).]]>1183186Zahin, M., F. Aqil and I. Ahmad,2009in vitro antioxidant activity and total phenolic content of four Indian medicinal plants.]]>18895Dengiz, G.O. and N. Gursan,2005Momordica charantia L. (Cucurbitaceae) on indomethacin induced ulcer model in rats.]]>168588Abdullin, I.F., E.N. Turova, G.K. Gaisina and G.K. Budnikov,200257557560Arawwawala, M., I. Thabrew, L. Arambewela and S. Handunnetti,2010Trichosanthes cucumerina Linn. in rats.]]>131538543