Asian Journal of Plant Sciences1682-39741812-5697Asian Network for Scientific Information10.3923/ajps.2010.134.139Zataria multiflora Boiss. Essential oil in Regulation of MDM2 and ATM Genes Expression in Rat]]>Vaziri GoharAli MohammadiAbbas SharififarFariba 3201093P53 tumor suppressor protein is a key component of genome guard. The p53 inactivation occurs frequently in many human cancers by mutation or over-expression of its specific inhibitor named MDM2 oncoprotein (Murine Double Minute-2), thus MDM2 inhibitors might offer the preventive and therapeutic strategies. In contrast, ATM (Ataxia Telangiectasia Mutated) tumor suppressor protein activates p53 protein. The MDM2 inhibitors such as Nutlin-3, HLI98 and MDM2 antisense oligonucleotides have been identified, but clinical validation is still pending. The Zataria multiflora Boiss. has antioxidant and antibacterial effects. To determine the correlation between the Zataria multiflora Boiss. and anti-carcinogenesis effects, we investigated the role of the essential oil of this plant on MDM2 and ATM genes expression using semi-quantitative RT-PCR in liver samples of 8 normal male rats. The results clearly showed that ATM and MDM2 gene expression increased and decreased, respectively, although the difference in ATM mRNA between target and control groups did not reach levels of significance. Our data implicated the essential oil of Zataria multiflora Boiss. as a down-regulator of MDM2 gene expression and may offer new tools for therapeutic intervention in the p53 pathway for cancer prevention and treatment.]]>Abraham, R.T.,20011521772196Ali, M.S., M. Saleem, Z. Ali and V.U. Ahmad,2000Multiflora (Lamiaceae).]]>55933936Ashcroft, M. and K.H. Vousden,19991876377643Banin, S., L. Moyal, S. Shieh, Y. Taya and C.W. Anderson et al.,199828116741677Bauer, S., T. Muhlenberg, M. Leahy, M. Hoiczyk, T. Gauler, M. Schuler and L. Looijenga,201057679687Cahilly-Snyder, L., T. Yang-Feng, U. Francke and D.L. George,198713235244Chen, L., S. Agrawal, W. Zhou, R. Zhang and J. Chen,199895195200Daferera, D.J., B.N. Ziogas and M.G. Polissiou,2000Penicillium digitatum.]]>4825762581Ebrahimzadeh, H., Y. Yamini, F. Sefidkon, M. Chaloosi and S.M. Pourmortazavi,2003Zataria multiflora Boiss.]]>83357361Fakharzadeh, S.S., S.P. Trusko and D.L. George,19911015651569Fazeli, M.R., G. Amin, M.M.A. Attari, H. Ashtiani, H. Jamalifar and N. Samadi,2007Zataria multiflora) against some food-borne bacteria.]]>18646649Goodarzi, A.A. and S.P. Lees-Miller,20043753767Halaby, M.J., J.C. Hibma, J. He and D.Q. Yang,20082015551563Halaschek-Wiener, J., V. Wacheck, Y. Kloog and B. Jansen,20041613191327Honda, R. and H. Yasuda,1999182227Honda, R. and H. Yasuda,20001914731476Hosseinzadeh, H., M. Ramezani and G.A. Salmani,2000Zataria multiflora boiss extracts in mice and rats.]]>73379385Koundrioukoff, S., S. Polo and G. Almouzni,20043969978Kubbutat, M.H.G., S.N. Jones and K.H. Vousden,1997387299303Kurz, E.U. and S.P. Lees-Miller,20043889900Liu, Z., E.T. Olejniczak and S.W. Fesik,200437493498Lowe, S.W. and C.J. Sherr,2003137783Maki, C.G., J.M. Huibregtse and P.M. Howley,1996In vivo ubiquitination and proteasome-mediated degradation of p53(1).]]>5626492654Meulmeester, E., Y. Pereg, Y. Shiloh and A.G. Jochemsen,2005411661170Michael, D. and M. Oren,2003134958Misaghi, A. and A.A. Basti,2007Multiflora Boiss. essential oil and nisin on Bacillus cereus ATCC 11778.]]>1810431049Mohammadi, A., A. Vaziri Gohar and M.R. Shakibaie,2008416Momand, J., D. Jung, S. Wilczynski and J. Niland,19982634533459Ng, I.O.L., K.Y. Lam, M. Ng and J.A. Regezi,1999356369Paranagama, P.A., K.H.T. Abeysekera, K. Abeywickrama and L. Nugaliyadde,2003Cymbopogon citratus (DC.) Stapf. (lemongrass) against Aspergillus flavus Link. isolated from stored rice.]]>378690Shafiee, A. and K. Javidnia,1997Zataria multiflora.]]>63371372Sharififar, F., M.H. Moshafi, S.H. Mansouri, M. Khodashenas and M. Khoshnoodi,2007In vitro evaluation of antibacterial and antioxidant activities of the essential oil and methanol extract of endemic Zataria multiflora Boiss.]]>18800805Sheng, Y., V. Saridakis, F. Sarkari, S. Duan and T. Wu et al.,200613285291Sherr, C.J.,20066663673Singh, G., S. Maurya, M.P. Lampasona and C. Catalan,200617745752Toledo, F. and G.M. Wahl,20073914761482Tortora, G., R. Caputo, V. Damiano, R. Bianco and J. Chen,200088804809Vassilev, L.T.,2007132331Vaziri Gohar, A., A. Mohammadi and M. Heidari,2007Velluti, A., V. Sanchis, A.J. Ramos, J. Egido and S. Marin,20031 production by Fusarium proliferatum in maize grain.]]>89145154Yang, J., Y. Yu, H.E. Hamrick and P.J. Duerksen-Hughes,20032415711580Yang, Y., R. Ludwig, J. Jensen, S. Pierre and M. Medaglia et al.,20057547559Zhang, R., H. Wang and S. Agrawal,2005in vitro and in vivo activities and mechanisms.]]>54349Zhang, Z., H. Wang, M. Li, S. Agrawal and X. Chen et al.,20042791600016006Zhou, B.P., Y. Liao, W. Xia, Y. Zou and B. Spohn et al.,20013973982