American Journal of Food Technology1557-45711557-458XAcademic Journals Inc.10.3923/ajft.2008.310.314OmerRehab AbuelgasimAfaf I. ElmahdiB. 5200835Twenty four Wistar albino rats were divided into 4 groups
and treated orally with potassium bromate at doses of 0, 50, 100 and 200
mg kg-1 body weight (b.wt.) for 21 days. Rats received 200
mg kg-1 b.wt. died within 18 days. A significant reduction
in Hb, PCV and MCHC values were observed in animals received 200 mg kg-1
b.wt. in the second week while no changes occurred in the groups treated
with 50 and 100 mg kg-1 b.wt. The activity of alanine transaminase
(ALT) was significantly increased in rats received 100 and 200 mg kg-1
b.wt. of potassium bromate from the first week, while total protein and
albumin were significantly decreased from the first week in animals treated
with 200 mg kg-1 b.wt. and the second week at the dose 100
mg kg-1 b.wt. Histologically liver degeneration and haemorrhage
was evident in the groups treated with 100 and 200 mg kg-1
b.wt. The dose of 50 mg kg-1 b.wt. did not cause any changes
compared to the control.]]>Chipman, J.K., J.K. Davies, J.L. Parson, J. Nair, G. O'Neill and J.K. Fawell,199812693102Drury, R.A.B. and E.A. Wallington,19805th Edn.,El-Sokkary, G.H.,200621461468FAO/WHO,19641964Khan, N., S. Sharma and S. Sultana,2003Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: Diminution of oxidative stress.]]>22193203Kurokawa, Y., A. Mackawa, N. Takahashi and Y. Hayeshi,199087309355Kutom, A., N.G. Bazilski, L. Magana and G. Deunea,1990158485Mendenhall, W.S.,19713rd Edn.Reinhold, J.C.,19535th Edn.Reitman, S. and S. Frankel,1957285663Sai, K., S. Vchiyama, Y. Ohno, R. Hasegawa and Y. Kurokawa,1992in vitro by the interaction of potassium bromate with rat kidney cell.]]>13333339Spencer, K. and G.P. Prince,19975th Edn.Ueno, H., K. Oishi, Y. Sayato and K. Nakamuno,20003816Umemura, T., K. Sai, A. Takagi, R. Hasigawa and Y. Kurokawa,199516593597