American Journal of Drug Discovery and Development2150-427x2150-4296Academic Journals Inc.10.3923/ajdd.2017.33.38SarwarA. RahmanM.S. HuqT.B. BiswasK. HussainM.I. ChaityJ.F. BegumT. HaqueMd. E. IslamA. BegumMst. M. 1201771Background and Objective: To compare the prevalence of acute vomiting between patients receiving cisplatin as monotherapy or cisplatin in a combination regimen. Materials and Methods: The study was conducted at Delta Hospital Dhaka on a total of 70 patients (44 male and 26 female). The patients received either cisplatin alone or cisplatin with the following chemotherapeutic agents-docetaxel and 5 fluorouracil, docetaxel, etoposide, doxorubicin and capecitabine. The study was conducted in patients receiving chemotherapy for a total of the first 3 cycles. The patients were told to record the number of episodes of vomiting they experienced during the first 24 h after chemotherapy at each cycle. All 70 patients received prechemotherapy antiemetics a combination of 5HT3 receptor antagonist (ondansetron or palanosetron) and dexamethasone prior to chemotherapy. Results: In patients receiving the combination chemotherapy of cisplatin+docetaxel+5 FU experienced the lowest incidence of acute vomiting and cisplatin+capecitabine receiving patients experienced highest incidence of acute vomiting. All the other combination therapy resulted in emesis comparatively similar to that of cisplatin. In all the regimens except for cisplatin+etoposide the percentage of patients experiencing acute vomiting reduced along with progressive cycles. Conclusion: When cisplatin is given in combination regimen except for the combination regimen of cisplatin+capecitabine there is no significant increase in emesis between patients receiving cisplatin alone or in combination therapy.]]>Coates, A., C.F. Dillenbeck, D.R. McNeil, S.B. Kaye and K. Sims et al.,19831916331637Hickok, J.T., J.A. Roscoe, G.R. Morrow, D.K. King, J.N. Atkins and T.R. Fitch,20039728802886Grunberg, S.M.,20042110Sanger, G.J. and P.L. Andrews,2006129316Aapro, M., A. Molassiotis, M. Dicato, I. Pelaez and A. Rodriguez-Lescure et al., 20122319861992Hesketh, P.J., M.G. Kris, S.M. Grunberg, T. Beck and J.D. Hainsworth et al.,199715103109Hesketh, P.J.,19994191196Hussain, S.A. and R. Sullivan,20131211591169Kamal Uddin, A.F.M., Z.J. Khan, J. Islam and A.M. Mahmud,20132102104Desoize, B. and C. Madoulet,200242317325Florea, A.M. and D. Busselberg,2011313511371Ali, I., W.A. Wani, K. Saleem and A. Haque,201313296306Aapro, M.S., S.M. Grunberg, G.M. Manikhas, G. Olivares and T. Suarez et al.,20061714411449Martin, M.,1996532631Osoba, D., B. Zee, D. Warr, L. Kaizer, J. Latreille and J. Pater,1996539295Osoba, D., B. Zee, D. Warr, J. Latreille, L. Kaizer and J. Pater,19975307313D'Acquisto, R.W., L.B. Tyson, R.J. Gralla, R.A. Clark, M.G. Kris, D.M. von Witte and A. Cacavio,19865257257Markman, M.,200269609610, 612, 615-617Marrow, G.R.,19855527662770Schnell, F.M.,20038187198Grunberg, S.M., R.R. Deuson, P. Mavros, O. Geling and M. Hansen et al.,200410022612668Gralla, R.J., D. Osoba, M.G. Kris, P. Kirkbride and P.J. Hesketh et al.,19991729712994Olver, I., W. Paska, A. Depierre, J.F. Seitz and D.J. Stewart et al.,19967945952Olver, I., R.A. Clark-Snow, E. Ballatori, B.T. Espersen, E. Bria and K. Jordan,2011193336Basch, E., A.A. Prestrud, P.J. Hesketh, M.G. Kris and P.C. Feyer et al.,20112941894198Hawkins, R. and S. Grunberg,2009135464Roila, F., J. Herrstedt, M. Aapro, R.J. Gralla and L.H. Einhorn et al.,201021v232v243Hesketh, P.J., S.M. Grunberg, R.J. Gralla, D.G. Warr and F. Roila et al.,20032141124119Schmoll, H.J., M.S. Aapro, S. Poli-Bigelli, H.K. Kim and K. Park et al.,20061710001006Takahashi, T., E. Hoshi, M. Takagi, N. Katsumata, M. Kawahara and K. Eguchi,201010124552461De Wit, R., J. Herrstedt, B. Rapoport, A.D. Carides and J. Guoguang-Ma et al.,20041 antagonist, aprepitant, given with standard antiemetics provides protection against nausea and vomiting over multiple cycles of cisplatin-based chemotherapy: A combined analysis of two randomised, placebo-controlled Phase III clinical trials.]]>40403410